Fields »

GENE INFORMATION

? »

Gene name

RAD50 (HGNC Symbol)

Synonyms

hRad50, RAD50-2

Description

RAD50 homolog (S. cerevisiae) (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Mutations in this gene are the cause of Nijmegen breakage syndrome-like disorder.[provided by RefSeq, Apr 2010]

Chromosome

5 (Chromosome progress)

Cytoband

q31.1

Chromosome location (bp)

131891711 - 131980313

Ensembl

ENSG00000113522 (version 69.37)

Entrez gene

10111

UniProt

Q92878

neXtProt

NX_Q92878

Antibodypedia

RAD50 antibodies
 

PROTEIN VIEW

? »
 
 
 
RAD50-001
 
RAD50-002
 
RAD50-003
 
RAD50-004
 
RAD50-005
 
RAD50-006
 
RAD50-009
 
RAD50-201
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

RAD50-001 ENSP00000265335
ENST00000265335
Q92878
Show all »
Show » Show » 1312 153.9 No 0
RAD50-002 ENSP00000431225
ENST00000533482
E9PM98
Show all »
102 11.4 No 0
RAD50-003 ENSP00000400049
ENST00000453394
E7EN38
Show all »
Show » 660 76.6 No 0
RAD50-004 ENSP00000390971
ENST00000423956
E7ESD9
Show all »
Show » 551 64.1 No 0
RAD50-005 ENSP00000396100
ENST00000434288
158 18.4 No 0
RAD50-006 ENSP00000389515
ENST00000416135
C9JNH8
Show all »
Show » 100 11.4 No 0
RAD50-009 ENSP00000396860
ENST00000455677
Show » 157 18.1 No 0
RAD50-201 ENSP00000368100
ENST00000378823
Q92878
Show all »
Show » Show » 1173 138.4 No 0