SKP1

GENE INFORMATION

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Gene name

SKP1 (HGNC Symbol)

Synonyms

EMC19, MGC34403, OCP-II, OCP2, p19A, SKP1A, TCEB1L

Description

S-phase kinase-associated protein 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a component of SCF complexes, which are composed of this protein, cullin 1, a ring-box protein, and one member of the F-box family of proteins. This protein binds directly to the F-box motif found in F-box proteins. SCF complexes are involved in the regulated ubiquitination of specific protein substrates, which targets them for degradation by the proteosome. Specific F-box proteins recognize different target protein(s), and many specific SCF substrates have been identified including regulators of cell cycle progression and development. Studies have also characterized the protein as an RNA polymerase II elongation factor. Alternative splicing of this gene results in two transcript variants. A related pseudogene has been identified on chromosome 7. [provided by RefSeq, Jul 2008]

Chromosome

5 (Chromosome progress)

Cytoband

q31.1

Chromosome location (bp)

133484633 - 133561762

Ensembl

ENSG00000113558 (version 73.37)

Entrez gene

6500

UniProt

P63208 (UniProt - Evidence at protein level)

neXtProt

NX_P63208

Antibodypedia

SKP1 antibodies
 

PROTEIN VIEW

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SKP1-001
 
SKP1-002
 
SKP1-003
 
SKP1-004
 
SKP1-005
 
SKP1-006
 
SKP1-007
 
SKP1-008
 
SKP1-009
 
SKP1-010
 
SKP1-011
 
SKP1-014
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SKP1-001 ENSP00000231487
ENST00000353411
P63208
Show all »
Show » 163 18.7 No 0
SKP1-002 ENSP00000429472
ENST00000522552
P63208
Show all »
Show » 160 18.1 No 0
SKP1-003 ENSP00000429415
ENST00000519321
E7ERH2
Show all »
Show » 142 16 No 0
SKP1-004 ENSP00000429961
ENST00000517625
P63208
Show all »
Show » 163 18.7 No 0
SKP1-005 ENSP00000429686
ENST00000522855
P63208
Show all »
Show » 163 18.7 No 0
SKP1-006 ENSP00000429996
ENST00000520417
E5RGM3
Show all »
Show » 102 11.6 No 0
SKP1-007 ENSP00000428962
ENST00000523359
Show » 18 2 No 0
SKP1-008 ENSP00000331708
ENST00000328392
F8W8N3
Show all »
Show » 158 17.9 No 0
SKP1-009 ENSP00000431067
ENST00000521216
E5RJR5
Show all »
Show » 163 18.7 No 0
SKP1-010 ENSP00000429995
ENST00000523966
E5RGM4
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Show » 41 4.6 No 0
SKP1-011 ENSP00000430885
ENST00000519054
E5RHM3
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Show » 39 4.3 No 0
SKP1-014 ENSP00000430774
ENST00000519718
E5RI56
Show all »
Show » 91 10.3 No 0