NR3C1

GENE INFORMATION

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Gene name

NR3C1 (HGNC Symbol)

Synonyms

GR, GRL

Description

nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) (HGNC Symbol)

Entrez gene summary

This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011]

Chromosome

5 (Chromosome progress)

Cytoband

q31.3

Chromosome location (bp)

142657496 - 142815077

Ensembl

ENSG00000113580 (version 73.37)

Entrez gene

2908

UniProt

P04150 (UniProt - Evidence at protein level)

neXtProt

NX_P04150

Antibodypedia

NR3C1 antibodies
 

PROTEIN VIEW

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 « 
 
NR3C1-001
 
NR3C1-002
 
NR3C1-003
 
NR3C1-004
 
NR3C1-005
 
NR3C1-006
 
NR3C1-007
 
NR3C1-008
 
NR3C1-009
 
NR3C1-010
 
NR3C1-013
 
NR3C1-201
 
NR3C1-202
 
NR3C1-203
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NR3C1-001 ENSP00000231509
ENST00000231509
P04150
Show all »
Show » Show » 778 85.8 No 0
NR3C1-002 ENSP00000377977
ENST00000394464
P04150
Show all »
Show » Show » 777 85.7 No 0
NR3C1-003 ENSP00000387672
ENST00000415690
P04150
Show all »
Show » Show » 742 81.5 No 0
NR3C1-004 ENSP00000424747
ENST00000510170
Q3MSN4
Show all »
Show » Show » 145 15.4 No 0
NR3C1-005 ENSP00000425313
ENST00000508760
Q3MSN4
Show all »
Show » Show » 145 15.4 No 0
NR3C1-006 ENSP00000377979
ENST00000394466
P04150
Show all »
Show » Show » 778 85.8 No 0
NR3C1-007 ENSP00000427672
ENST00000503201
P04150
Show all »
Show » Show » 777 85.7 No 0
NR3C1-008 ENSP00000420856
ENST00000502892
Q3MSN4
Show all »
Show » Show » 145 15.4 No 0
NR3C1-009 ENSP00000426478
ENST00000514699
Q3MSN4
Show all »
Show » Show » 145 15.4 No 0
NR3C1-010 ENSP00000422518
ENST00000504572
P04150
Show all »
Show » Show » 778 85.8 No 0
NR3C1-013 ENSP00000425374
ENST00000502500
D6RDA9
Show all »
Show » Show » 144 15.3 No 0
NR3C1-201 ENSP00000343205
ENST00000343796
P04150
Show all »
Show » Show » 777 85.7 No 0
NR3C1-202 ENSP00000404218
ENST00000416954
B7Z7I2
Show all »
Show » Show » 380 43.1 No 0
NR3C1-203 ENSP00000405282
ENST00000424646
P04150
Show all »
Show » Show » 751 82.9 No 0