ATP6V0E1

GENERAL INFORMATION

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Gene name

ATP6V0E1

Gene description

ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1

Protein class

Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

4
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at transcript level

ANTIBODY RELIABILITY

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Data reliability

Pending normal tissue annotation.
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Kidney & urinary bladder
N/A
Male tissues
N/A
Testis
N/A
Epididymis
N/A
N/A
Prostate
N/A
Seminal vesicle
N/A
N/A
Female tissues
N/A
Breast
N/A
N/A
Vagina
N/A
N/A
Cervix, uterine
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Skin
N/A
Skin
N/A


PROTEIN EXPRESSION OVERVIEW

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Pending normal tissue annotation.


RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

ATP6V0E1 (HGNC Symbol)

Synonyms

ATP6H, ATP6V0E, M9.2

Description

ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1 (HGNC Symbol)

Entrez gene summary

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c"", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is possibly part of the V0 subunit. Since two nontranscribed pseudogenes have been found in dog, it is possible that the localization to chromosome 2 for this gene by radiation hybrid mapping is representing a pseudogene. Genomic mapping puts the chromosomal location on 5q35.3. [provided by RefSeq, Jul 2008]

Chromosome

5

Cytoband

q35.1

Chromosome location (bp)

172983757 - 173035445

Protein evidence

Evidence at transcript level (all genes)

Ensembl

ENSG00000113732 (version 78.38)

Entrez gene

8992

UniProt

O15342 (UniProt - Evidence at transcript level)

neXtProt

NX_O15342

Antibodypedia

ATP6V0E1 antibodies


PROTEIN BROWSER

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ENST00000265093
 
ENST00000517669
 
ENST00000519374
 
ENST00000519911
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ATP6V0E1-001 ENSP00000429690
ENST00000519374
O15342
Show all »
Show » Show » 81 9.4 No 2
ATP6V0E1-002 ENSP00000430896
ENST00000519911
E5RHL5
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Show » Show » 58 6.5 No 2
ATP6V0E1-003 ENSP00000265093
ENST00000265093
J3KN48
Show all »
Show » Show » 65 7.6 No 1
ATP6V0E1-004 ENSP00000427941
ENST00000517669
O15342
Show all »
Show » Show » 81 9.4 No 2