BCL6

GENE INFORMATION

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Gene name

BCL6 (HGNC Symbol)

Synonyms

BCL5, BCL6A, LAZ3, ZBTB27, ZNF51

Description

B-cell CLL/lymphoma 6 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

Chromosome

3 (Chromosome progress)

Cytoband

q27.3

Chromosome location (bp)

187439165 - 187463515

Ensembl

ENSG00000113916 (version 73.37)

Entrez gene

604

UniProt

P41182 (UniProt - Evidence at protein level)

neXtProt

NX_P41182

Antibodypedia

BCL6 antibodies
 

PROTEIN VIEW

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BCL6-001
 
BCL6-003
 
BCL6-004
 
BCL6-007
 
BCL6-008
 
BCL6-010
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

BCL6-001 ENSP00000384371
ENST00000406870
P41182
Show all »
Show » Show » 706 78.8 No 0
BCL6-003 ENSP00000398014
ENST00000419510
Show » Show » 55 6.2 No 0
BCL6-004 ENSP00000232014
ENST00000232014
P41182
Show all »
Show » Show » 706 78.8 No 0
BCL6-007 ENSP00000414455
ENST00000438077
C9JL16
Show all »
Show » Show » 104 11.8 No 0
BCL6-008 ENSP00000415574
ENST00000430339
C9JCS5
Show all »
Show » Show » 122 13.9 No 0
BCL6-010 ENSP00000413122
ENST00000450123
P41182
Show all »
Show » Show » 650 72.4 No 0