CLDN16

GENE INFORMATION

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Gene name

CLDN16 (HGNC Symbol)

Synonyms

HOMG3, PCLN1

Description

claudin 16 (HGNC Symbol)

Entrez gene summary

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is found primarily in the kidneys, specifically in the thick ascending limb of Henle, where it acts as either an intercellular pore or ion concentration sensor to regulate the paracellular resorption of magnesium ions. Defects in this gene are a cause of primary hypomagnesemia, which is characterized by massive renal magnesium wasting with hypomagnesemia and hypercalciuria, resulting in nephrocalcinosis and renal failure. This gene and the CLDN1 gene are clustered on chromosome 3q28. [provided by RefSeq, Jun 2010]

Chromosome

3 (Chromosome progress)

Cytoband

q28

Chromosome location (bp)

190040330 - 190129932

Ensembl

ENSG00000113946 (version 73.37)

Entrez gene

10686

UniProt

Q9Y5I7 (UniProt - Evidence at protein level)

neXtProt

NX_Q9Y5I7

Antibodypedia

CLDN16 antibodies
 

PROTEIN VIEW

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CLDN16-001
 
CLDN16-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CLDN16-001 ENSP00000264734
ENST00000264734
Q9Y5I7
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Show » Show » 305 33.8 No 4
CLDN16-002 ENSP00000414136
ENST00000456423
A0SDD8
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Show » Show » 119 13.5 No 1