UMPS

GENE INFORMATION

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Gene name

UMPS

Synonyms

Description

uridine monophosphate synthetase (HGNC Symbol)

Entrez gene summary

This gene encodes a uridine 5'-monophosphate synthase. The encoded protein is a bifunctional enzyme that catalyzes the final two steps of the de novo pyrimidine biosynthetic pathway. The first reaction is carried out by the N-terminal enzyme orotate phosphoribosyltransferase which converts orotic acid to orotidine-5'-monophosphate. The terminal reaction is carried out by the C-terminal enzyme OMP decarboxylase which converts orotidine-5'-monophosphate to uridine monophosphate. Defects in this gene are the cause of hereditary orotic aciduria. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

Chromosome

3 (Chromosome progress)

Cytoband

q21.2

Chromosome location (bp)

124449213 - 124464040

Ensembl

ENSG00000114491 (version 73.37)

Entrez gene

7372

UniProt

P11172 (UniProt - Evidence at protein level)

neXtProt

NX_P11172

Antibodypedia

UMPS antibodies
 

PROTEIN VIEW

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UMPS-001
 
UMPS-002
 
UMPS-004
 
UMPS-005
 
UMPS-006
 
UMPS-008
 
UMPS-009
 
UMPS-201
 
UMPS-202
 
UMPS-203
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

UMPS-001 ENSP00000232607
ENST00000232607
P11172
Show all »
Show » Show » 480 52.2 No 0
UMPS-002 ENSP00000417893
ENST00000462091
F2Z3P2
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57 6.2 No 0
UMPS-004 ENSP00000420348
ENST00000474588
F8WDG4
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Show » Show » 142 15.3 No 0
UMPS-005 ENSP00000419121
ENST00000497791
F2Z3P2
Show all »
57 6.2 No 0
UMPS-006 ENSP00000420409
ENST00000460034
F2Z303
Show all »
66 7.1 No 0
UMPS-008 ENSP00000419618
ENST00000467167
F2Z303
Show all »
66 7.1 No 0
UMPS-009 ENSP00000420754
ENST00000479719
E9PFD2
Show all »
Show » Show » 342 37.6 No 0
UMPS-201 ENSP00000397965
ENST00000413078
B5LY72
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Show » 205 22.9 No 0
UMPS-202 ENSP00000443577
ENST00000536109
B5LY68
Show all »
Show » 388 42.5 No 0
UMPS-203 ENSP00000444988
ENST00000538242
P11172
Show all »
Show » Show » 302 33.1 No 0