ATP6V1A

GENE INFORMATION

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Gene name

ATP6V1A (HGNC Symbol)

Synonyms

ATP6A1, ATP6V1A1, VA68, Vma1, VPP2

Description

ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A (HGNC Symbol)

Entrez gene summary

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c"", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is one of two V1 domain A subunit isoforms and is found in all tissues. Transcript variants derived from alternative polyadenylation exist. [provided by RefSeq, Jul 2008]

Chromosome

3 (Chromosome progress)

Cytoband

q13.2

Chromosome location (bp)

113465866 - 113530903

Ensembl

ENSG00000114573 (version 73.37)

Entrez gene

523

UniProt

P38606 (UniProt - Evidence at protein level)

neXtProt

NX_P38606

Antibodypedia

ATP6V1A antibodies
 

PROTEIN VIEW

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ATP6V1A-001
 
ATP6V1A-002
 
ATP6V1A-005
 
ATP6V1A-006
 
ATP6V1A-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ATP6V1A-001 ENSP00000273398
ENST00000273398
P38606
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Show » Show » 617 68.3 No 0
ATP6V1A-002 ENSP00000420146
ENST00000470455
F8WDJ3
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49 5.4 No 0
ATP6V1A-005 ENSP00000419294
ENST00000475322
C9JVW8
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Show » 221 24.2 No 0
ATP6V1A-006 ENSP00000417545
ENST00000496747
C9JA17
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Show » 185 20.2 No 0
ATP6V1A-201 ENSP00000439874
ENST00000538620
B7Z1R5
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Show » 584 64.7 No 0