SCAP

GENERAL INFORMATION

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Gene name

SCAP

Gene description

SREBF chaperone

Protein class

Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

6
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

A majority of normal tissues displayed moderate to strong cytoplasmic immunoreactivity. Strongest positivity was found in glandular epithelia.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA004713
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Stomach

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

SCAP (HGNC Symbol)

Synonyms

KIAA0199

Description

SREBF chaperone (HGNC Symbol)

Entrez gene summary

This gene encodes a protein with a sterol sensing domain (SSD) and seven WD domains. In the presence of cholesterol, this protein binds to sterol regulatory element binding proteins (SREBPs) and mediates their transport from the ER to the Golgi. The SREBPs are then proteolytically cleaved and regulate sterol biosynthesis. [provided by RefSeq, Jul 2008]

Chromosome

3

Cytoband

p21.31

Chromosome location (bp)

47413694 - 47477126

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000114650 (version 78.38)

Entrez gene

22937

UniProt

Q12770 (UniProt - Evidence at protein level)

neXtProt

NX_Q12770

Antibodypedia

SCAP antibodies


PROTEIN BROWSER

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ENST00000265565
 
ENST00000416847
 
ENST00000428413
 
ENST00000448217
 
ENST00000495603
 
ENST00000545718
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SCAP-001 ENSP00000265565
ENST00000265565
Q12770
Show all »
Show » Show » 1279 139.7 No 8
SCAP-006 ENSP00000415195
ENST00000448217
C9JFY0
Show all »
Show » 88 9.9 No 1
SCAP-007 ENSP00000408102
ENST00000416847
C9JQ35
Show all »
Show » 136 15.5 No 1
SCAP-008 ENSP00000423419
ENST00000495603
D6RA39
Show all »
Show » 132 15 No 1
SCAP-201 ENSP00000401819
ENST00000428413
Show » Show » 352 38.2 No 2
SCAP-202 ENSP00000438956
ENST00000545718
Show » Show » 905 97.9 No 4