CISH

GENE INFORMATION

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Gene name

CISH (HGNC Symbol)

Synonyms

CIS, CIS-1, G18, SOCS

Description

Cytokine inducible SH2-containing protein (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

Chromosome

3

Cytoband

p21.2

Chromosome location (bp)

50643921 - 50649262

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000114737 (version 75.37)

Entrez gene

1154

UniProt

Q9NSE2 (UniProt - Evidence at protein level)

neXtProt

NX_Q9NSE2

Antibodypedia

CISH antibodies
 

PROTEIN VIEW

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CISH-001
 
CISH-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CISH-001 ENSP00000294173
ENST00000348721
Q9NSE2
Show all »
Show » 258 28.7 No 0
CISH-002 ENSP00000409346
ENST00000443053
Q9NSE2
Show all »
Show » 275 30.7 No 0