CISH

GENERAL INFORMATION

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Gene name

CISH

Gene description

Cytokine inducible SH2-containing protein

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Mixed
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

General cytoplasmic expression.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 2 antibodies.
HPA040812 , CAB034039
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Mixed

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

CISH (HGNC Symbol)

Synonyms

CIS, CIS-1, G18, SOCS

Description

Cytokine inducible SH2-containing protein (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

Chromosome

3

Cytoband

p21.2

Chromosome location (bp)

50606490 - 50611831

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000114737 (version 78.38)

Entrez gene

1154

UniProt

Q9NSE2 (UniProt - Evidence at protein level)

neXtProt

NX_Q9NSE2

Antibodypedia

CISH antibodies


PROTEIN BROWSER

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ENST00000348721
 
ENST00000443053
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CISH-001 ENSP00000294173
ENST00000348721
Q9NSE2
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Show » Show » 258 28.7 No 0
CISH-002 ENSP00000409346
ENST00000443053
Q9NSE2
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Show » Show » 275 30.7 No 0