MAPKAPK3

GENE INFORMATION

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Gene name

MAPKAPK3 (HGNC Symbol)

Synonyms

3pK, MAPKAP3

Description

mitogen-activated protein kinase-activated protein kinase 3 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the Ser/Thr protein kinase family. This kinase functions as a mitogen-activated protein kinase (MAP kinase)- activated protein kinase. MAP kinases are also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This kinase was shown to be activated by growth inducers and stress stimulation of cells. In vitro studies demonstrated that ERK, p38 MAP kinase and Jun N-terminal kinase were all able to phosphorylate and activate this kinase, which suggested the role of this kinase as an integrative element of signaling in both mitogen and stress responses. This kinase was reported to interact with, phosphorylate and repress the activity of E47, which is a basic helix-loop-helix transcription factor known to be involved in the regulation of tissue-specific gene expression and cell differentiation. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011]

Chromosome

3 (Chromosome progress)

Cytoband

p21.2

Chromosome location (bp)

50648951 - 50686720

Ensembl

ENSG00000114738 (version 73.37)

Entrez gene

7867

UniProt

Q16644 (UniProt - Evidence at protein level)

neXtProt

NX_Q16644

Antibodypedia

MAPKAPK3 antibodies
 

PROTEIN VIEW

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MAPKAPK3-001
 
MAPKAPK3-002
 
MAPKAPK3-005
 
MAPKAPK3-006
 
MAPKAPK3-007
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MAPKAPK3-001 ENSP00000350639
ENST00000357955
Q16644
Show all »
Show » Show » 382 43 No 1
MAPKAPK3-002 ENSP00000396467
ENST00000446044
Q16644
Show all »
Show » Show » 382 43 No 1
MAPKAPK3-005 ENSP00000410970
ENST00000430409
C9J8E1
Show all »
Show » Show » 332 37.4 No 1
MAPKAPK3-006 ENSP00000402045
ENST00000457064
C9JPW3
Show all »
Show » 119 12.9 No 0
MAPKAPK3-007 ENSP00000394894
ENST00000451680
Show » 97 11 No 0