ACVR2B

GENE INFORMATION

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Gene name

ACVR2B (HGNC Symbol)

Synonyms

ActR-IIB

Description

activin A receptor, type IIB (HGNC Symbol)

Entrez gene summary

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. [provided by RefSeq, Jul 2008]

Chromosome

3 (Chromosome progress)

Cytoband

p22.2

Chromosome location (bp)

38495342 - 38524948

Ensembl

ENSG00000114739 (version 73.37)

Entrez gene

93

UniProt

Q13705 (UniProt - Evidence at protein level)

neXtProt

NX_Q13705

Antibodypedia

ACVR2B antibodies
 

PROTEIN VIEW

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ACVR2B-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ACVR2B-001 ENSP00000340361
ENST00000352511
Q13705
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