ABCC5

GENE INFORMATION

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Gene name

ABCC5 (HGNC Symbol)

Synonyms

EST277145, MOAT-C, MRP5, SMRP

Description

ATP-binding cassette, sub-family C (CFTR/MRP), member 5 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing of this gene has been detected; however, the complete sequence and translation initiation site is unclear. [provided by RefSeq, Jul 2008]

Chromosome

3 (Chromosome progress)

Cytoband

q27.1

Chromosome location (bp)

183637722 - 183735803

Ensembl

ENSG00000114770 (version 73.37)

Entrez gene

10057

UniProt

O15440 (UniProt - Evidence at protein level)

neXtProt

NX_O15440

Antibodypedia

ABCC5 antibodies
 

PROTEIN VIEW

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 « 
 
ABCC5-001
 
ABCC5-002
 
ABCC5-003
 
ABCC5-004
 
ABCC5-005
 
ABCC5-006
 
ABCC5-007
 
ABCC5-009
 
ABCC5-010
 
ABCC5-013
 
ABCC5-201
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ABCC5-001 ENSP00000333926
ENST00000334444
O15440
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Show » Show » 1437 160.7 No >9
ABCC5-002 ENSP00000390911
ENST00000446941
E9PET4
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53 6.2 No 0
ABCC5-003 ENSP00000416840
ENST00000443376
O15440
Show all »
Show » Show » 212 24 No 1
ABCC5-004 ENSP00000376358
ENST00000392579
O15440
Show all »
Show » Show » 225 25.3 No 1
ABCC5-005 ENSP00000371934
ENST00000382494
O15440
Show all »
Show » Show » 208 23.7 No 1
ABCC5-006 ENSP00000404809
ENST00000427120
A5PKY6
Show all »
Show » 231 26.2 No 1
ABCC5-007 ENSP00000403510
ENST00000437205
F8WCY8
Show all »
Show » Show » 473 53 No 5
ABCC5-009 ENSP00000409913
ENST00000438979
F8WDH3
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53 6.3 No 0
ABCC5-010 ENSP00000399726
ENST00000437341
C9JZL5
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147 16.7 No 0
ABCC5-013 ENSP00000404302
ENST00000443497
70 7.9 No 0
ABCC5-201 ENSP00000265586
ENST00000265586
Q86UX3
Show all »
Show » Show » 1394 155.7 No >9