ARHGEF26

GENERAL INFORMATION

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Gene name

ARHGEF26

Gene description

Rho guanine nucleotide exchange factor (GEF) 26

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Mixed
GTEx:Mixed

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic staining in a few tissues. Strongest staining in heart, smooth and skeletal muscle cells and squamous epithelia. Extracellular staining was also seen in goblet cells in e.g. gastrointestinal tract. Most other normal tissues were weakly stained or negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA017722
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Mixed

Organ

Expression

GTEx dataset
RNA tissue category:  Mixed

Organ

Expression



GENE INFORMATION

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Gene name

ARHGEF26 (HGNC Symbol)

Synonyms

DKFZP434D146, SGEF

Description

Rho guanine nucleotide exchange factor (GEF) 26 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the Rho-guanine nucleotide exchange factor (Rho-GEF) family. These proteins regulate Rho GTPases by catalyzing the exchange of GDP for GTP. The encoded protein specifically activates RhoG and plays a role in the promotion of macropinocytosis. Underexpression of the encoded protein may be a predictive marker of chemoresistant disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]

Chromosome

3

Cytoband

q25.2

Chromosome location (bp)

154121003 - 154257827

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000114790 (version 78.38)

Entrez gene

26084

UniProt

Q96DR7 (UniProt - Evidence at protein level)

neXtProt

NX_Q96DR7

Antibodypedia

ARHGEF26 antibodies


PROTEIN BROWSER

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ENST00000356448
 
ENST00000465093
 
ENST00000465817
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ARHGEF26-001 ENSP00000348828
ENST00000356448
Q96DR7
Show all »
Show » Show » 871 97.3 No 0
ARHGEF26-002 ENSP00000423418
ENST00000465093
Q96DR7
Show all »
Show » Show » 871 97.3 No 0
ARHGEF26-004 ENSP00000423295
ENST00000465817
Q96DR7
Show all »
Show » Show » 446 48.2 No 0