The Human Protein Atlas

GENE INFORMATION

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Gene name	FOXP1 (HGNC Symbol)
Synonyms	12CC4, hFKH1B, HSPC215, QRF1
Description	forkhead box P1 (HGNC Symbol)
Entrez gene summary	This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Chromosome	3 (Chromosome progress)
Cytoband	p13
Chromosome location (bp)	71003844 - 71633140
Ensembl	ENSG00000114861 (version 69.37)
Entrez gene	27086
UniProt	Q9H334
neXtProt	NX_Q9H334
Antibodypedia	FOXP1 antibodies

PROTEIN VIEW

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FOXP1-001		FOXP1-002		FOXP1-003		FOXP1-004		FOXP1-005		FOXP1-006		FOXP1-009		FOXP1-011		FOXP1-012		FOXP1-014		FOXP1-019		FOXP1-021

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
FOXP1-001	ENSP00000318902 ENST00000318789	Q9H334 Show all » « Hide Q9H334 [Direct mapping] Forkhead box protein P1 Q548T7 [Target identity:100%; Query identity:100%] 12CC4; Forkhead box P1, isoform CRA_a B4DMV4 [Target identity:79%; Query identity:100%] cDNA FLJ58267, highly similar to Forkhead box protein P1 Q8IXF4 [Target identity:60%; Query identity:100%] Fork head-related protein like B C9J5T4 [Target identity:33%; Query identity:100%] Forkhead box protein P1 C9IYY1 [Target identity:18%; Query identity:100%] Forkhead box protein P1	Show » « Hide Transcription factors Mutated genes in cancer Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001701 [in utero embryonic development] GO:0002053 [positive regulation of mesenchymal cell proliferation] GO:0002329 [pre-B cell differentiation] GO:0002639 [positive regulation of immunoglobulin production] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003690 [double-stranded DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003705 [RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity] GO:0005634 [nucleus] GO:0005667 [transcription factor complex] GO:0005737 [cytoplasm] GO:0007389 [pattern specification process] GO:0007507 [heart development] GO:0007519 [skeletal muscle tissue development] GO:0008045 [motor axon guidance] GO:0008134 [transcription factor binding] GO:0008270 [zinc ion binding] GO:0008301 [DNA binding, bending] GO:0009790 [embryo development] GO:0021517 [ventral spinal cord development] GO:0030324 [lung development] GO:0033152 [immunoglobulin V(D)J recombination] GO:0042803 [protein homodimerization activity] GO:0043565 [sequence-specific DNA binding] GO:0045214 [sarcomere organization] GO:0045892 [negative regulation of transcription, DNA-dependent] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046982 [protein heterodimerization activity] GO:0048745 [smooth muscle tissue development] GO:0050679 [positive regulation of epithelial cell proliferation] GO:0051090 [regulation of sequence-specific DNA binding transcription factor activity] GO:0055007 [cardiac muscle cell differentiation] GO:0060043 [regulation of cardiac muscle cell proliferation] GO:0060501 [positive regulation of epithelial cell proliferation involved in lung morphogenesis] GO:0072358 [cardiovascular system development] GO:2000727 [positive regulation of cardiac muscle cell differentiation]	677	75.3	No	0
FOXP1-002	ENSP00000418524 ENST00000493089	G5E9V8 Show all » « Hide G5E9V8 [Target identity:100%; Query identity:100%] Forkhead box P1, isoform CRA_d; Forkhead box protein P1 C9J5T4 [Target identity:33%; Query identity:100%] Forkhead box protein P1 C9IYY1 [Target identity:18%; Query identity:100%] Forkhead box protein P1	Show » « Hide Transcription factors Mutated genes in cancer	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001701 [in utero embryonic development] GO:0002053 [positive regulation of mesenchymal cell proliferation] GO:0002329 [pre-B cell differentiation] GO:0002639 [positive regulation of immunoglobulin production] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003705 [RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0007519 [skeletal muscle tissue development] GO:0008045 [motor axon guidance] GO:0008270 [zinc ion binding] GO:0021517 [ventral spinal cord development] GO:0030324 [lung development] GO:0033152 [immunoglobulin V(D)J recombination] GO:0042803 [protein homodimerization activity] GO:0043565 [sequence-specific DNA binding] GO:0045214 [sarcomere organization] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046982 [protein heterodimerization activity] GO:0048745 [smooth muscle tissue development] GO:0050679 [positive regulation of epithelial cell proliferation] GO:0055007 [cardiac muscle cell differentiation] GO:0060043 [regulation of cardiac muscle cell proliferation] GO:2000727 [positive regulation of cardiac muscle cell differentiation]	676	75.2	No	0
FOXP1-003	ENSP00000333560 ENST00000327590	G5E965 Show all » « Hide G5E965 [Target identity:100%; Query identity:100%] Forkhead box P1, isoform CRA_f; Forkhead box protein P1 C9J5T4 [Target identity:39%; Query identity:100%] Forkhead box protein P1 C9IYY1 [Target identity:21%; Query identity:100%] Forkhead box protein P1	Show » « Hide Transcription factors Mutated genes in cancer	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001701 [in utero embryonic development] GO:0002053 [positive regulation of mesenchymal cell proliferation] GO:0002329 [pre-B cell differentiation] GO:0002639 [positive regulation of immunoglobulin production] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003705 [RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0007519 [skeletal muscle tissue development] GO:0008045 [motor axon guidance] GO:0008270 [zinc ion binding] GO:0021517 [ventral spinal cord development] GO:0030324 [lung development] GO:0033152 [immunoglobulin V(D)J recombination] GO:0042803 [protein homodimerization activity] GO:0043565 [sequence-specific DNA binding] GO:0045214 [sarcomere organization] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046982 [protein heterodimerization activity] GO:0048745 [smooth muscle tissue development] GO:0050679 [positive regulation of epithelial cell proliferation] GO:0055007 [cardiac muscle cell differentiation] GO:0060043 [regulation of cardiac muscle cell proliferation] GO:2000727 [positive regulation of cardiac muscle cell differentiation]	566	63.2	No	0
FOXP1-004	ENSP00000419393 ENST00000475937	Q9H334 Show all » « Hide Q9H334 [Direct mapping] Forkhead box protein P1 Q548T7 [Target identity:100%; Query identity:100%] 12CC4; Forkhead box P1, isoform CRA_a B4DMV4 [Target identity:79%; Query identity:100%] cDNA FLJ58267, highly similar to Forkhead box protein P1 Q8IXF4 [Target identity:60%; Query identity:100%] Fork head-related protein like B C9J5T4 [Target identity:33%; Query identity:100%] Forkhead box protein P1 C9IYY1 [Target identity:18%; Query identity:100%] Forkhead box protein P1	Show » « Hide Transcription factors Mutated genes in cancer Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001701 [in utero embryonic development] GO:0002053 [positive regulation of mesenchymal cell proliferation] GO:0002329 [pre-B cell differentiation] GO:0002639 [positive regulation of immunoglobulin production] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003690 [double-stranded DNA binding] GO:0003705 [RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity] GO:0005634 [nucleus] GO:0005667 [transcription factor complex] GO:0005737 [cytoplasm] GO:0007389 [pattern specification process] GO:0007519 [skeletal muscle tissue development] GO:0008045 [motor axon guidance] GO:0008134 [transcription factor binding] GO:0008270 [zinc ion binding] GO:0008301 [DNA binding, bending] GO:0009790 [embryo development] GO:0021517 [ventral spinal cord development] GO:0030324 [lung development] GO:0033152 [immunoglobulin V(D)J recombination] GO:0042803 [protein homodimerization activity] GO:0043565 [sequence-specific DNA binding] GO:0045214 [sarcomere organization] GO:0045892 [negative regulation of transcription, DNA-dependent] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046982 [protein heterodimerization activity] GO:0048745 [smooth muscle tissue development] GO:0050679 [positive regulation of epithelial cell proliferation] GO:0051090 [regulation of sequence-specific DNA binding transcription factor activity] GO:0055007 [cardiac muscle cell differentiation] GO:0060043 [regulation of cardiac muscle cell proliferation] GO:0060501 [positive regulation of epithelial cell proliferation involved in lung morphogenesis] GO:2000727 [positive regulation of cardiac muscle cell differentiation]	677	75.3	No	0
FOXP1-005	ENSP00000417857 ENST00000484350	Q8NAN6 Show all » « Hide Q8NAN6 [Target identity:100%; Query identity:100%] Forkhead box protein P1; cDNA FLJ35064 fis, clone PEBLM1000147, moderately similar to Glutamine (Q)-rich factor 1, QRF-1 Q8IXF4 [Target identity:67%; Query identity:100%] Fork head-related protein like B	Show » « Hide Transcription factors Mutated genes in cancer	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005634 [nucleus] GO:0008270 [zinc ion binding] GO:0043565 [sequence-specific DNA binding]	601	66.4	No	0
FOXP1-006	ENSP00000418102 ENST00000498215	Q9H334 Show all » « Hide Q9H334 [Direct mapping] Forkhead box protein P1 Q548T7 [Target identity:100%; Query identity:100%] 12CC4; Forkhead box P1, isoform CRA_a B4DMV4 [Target identity:79%; Query identity:100%] cDNA FLJ58267, highly similar to Forkhead box protein P1 Q8IXF4 [Target identity:60%; Query identity:100%] Fork head-related protein like B C9J5T4 [Target identity:33%; Query identity:100%] Forkhead box protein P1 C9IYY1 [Target identity:18%; Query identity:100%] Forkhead box protein P1	Show » « Hide Transcription factors Mutated genes in cancer Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001701 [in utero embryonic development] GO:0002053 [positive regulation of mesenchymal cell proliferation] GO:0002329 [pre-B cell differentiation] GO:0002639 [positive regulation of immunoglobulin production] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003690 [double-stranded DNA binding] GO:0003705 [RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity] GO:0005634 [nucleus] GO:0005667 [transcription factor complex] GO:0005737 [cytoplasm] GO:0007389 [pattern specification process] GO:0007519 [skeletal muscle tissue development] GO:0008045 [motor axon guidance] GO:0008134 [transcription factor binding] GO:0008270 [zinc ion binding] GO:0008301 [DNA binding, bending] GO:0009790 [embryo development] GO:0021517 [ventral spinal cord development] GO:0030324 [lung development] GO:0033152 [immunoglobulin V(D)J recombination] GO:0042803 [protein homodimerization activity] GO:0043565 [sequence-specific DNA binding] GO:0045214 [sarcomere organization] GO:0045892 [negative regulation of transcription, DNA-dependent] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046982 [protein heterodimerization activity] GO:0048745 [smooth muscle tissue development] GO:0050679 [positive regulation of epithelial cell proliferation] GO:0051090 [regulation of sequence-specific DNA binding transcription factor activity] GO:0055007 [cardiac muscle cell differentiation] GO:0060043 [regulation of cardiac muscle cell proliferation] GO:0060501 [positive regulation of epithelial cell proliferation involved in lung morphogenesis] GO:2000727 [positive regulation of cardiac muscle cell differentiation]	677	75.3	No	0
FOXP1-009	ENSP00000418225 ENST00000497355	H0Y882 Show all » « Hide H0Y882 [Target identity:100%; Query identity:100%] Forkhead box protein P1 Q8IXF4 [Target identity:71%; Query identity:100%] Fork head-related protein like B	Show » « Hide Transcription factors Mutated genes in cancer	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005622 [intracellular] GO:0008270 [zinc ion binding] GO:0043565 [sequence-specific DNA binding]	573	64	No	0
FOXP1-011	ENSP00000420736 ENST00000491238	E9PFD3 Show all » « Hide E9PFD3 [Target identity:100%; Query identity:100%] Forkhead box protein P1 B4DMV4 [Target identity:79%; Query identity:100%] cDNA FLJ58267, highly similar to Forkhead box protein P1 Q8IXF4 [Target identity:59%; Query identity:100%] Fork head-related protein like B C9J5T4 [Target identity:32%; Query identity:100%] Forkhead box protein P1 C9IYY1 [Target identity:18%; Query identity:100%] Forkhead box protein P1	Show » « Hide Transcription factors Mutated genes in cancer	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001701 [in utero embryonic development] GO:0002053 [positive regulation of mesenchymal cell proliferation] GO:0002329 [pre-B cell differentiation] GO:0002639 [positive regulation of immunoglobulin production] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003705 [RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity] GO:0005634 [nucleus] GO:0007519 [skeletal muscle tissue development] GO:0008045 [motor axon guidance] GO:0008270 [zinc ion binding] GO:0021517 [ventral spinal cord development] GO:0030324 [lung development] GO:0033152 [immunoglobulin V(D)J recombination] GO:0042803 [protein homodimerization activity] GO:0043565 [sequence-specific DNA binding] GO:0045214 [sarcomere organization] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046982 [protein heterodimerization activity] GO:0048745 [smooth muscle tissue development] GO:0050679 [positive regulation of epithelial cell proliferation] GO:0055007 [cardiac muscle cell differentiation] GO:0060043 [regulation of cardiac muscle cell proliferation] GO:2000727 [positive regulation of cardiac muscle cell differentiation]	679	76.3	No	0
FOXP1-012	ENSP00000418883 ENST00000468577	C9J0F0 Show all » « Hide C9J0F0 [Target identity:100%; Query identity:100%] Forkhead box protein P1 C9J5T4 [Target identity:36%; Query identity:100%] Forkhead box protein P1 C9IYY1 [Target identity:20%; Query identity:100%] Forkhead box protein P1	Show » « Hide Transcription factors Mutated genes in cancer	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001701 [in utero embryonic development] GO:0002053 [positive regulation of mesenchymal cell proliferation] GO:0002329 [pre-B cell differentiation] GO:0002639 [positive regulation of immunoglobulin production] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003705 [RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity] GO:0005634 [nucleus] GO:0007519 [skeletal muscle tissue development] GO:0008045 [motor axon guidance] GO:0008270 [zinc ion binding] GO:0021517 [ventral spinal cord development] GO:0030324 [lung development] GO:0033152 [immunoglobulin V(D)J recombination] GO:0042803 [protein homodimerization activity] GO:0043565 [sequence-specific DNA binding] GO:0045214 [sarcomere organization] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046982 [protein heterodimerization activity] GO:0048745 [smooth muscle tissue development] GO:0050679 [positive regulation of epithelial cell proliferation] GO:0055007 [cardiac muscle cell differentiation] GO:0060043 [regulation of cardiac muscle cell proliferation] GO:2000727 [positive regulation of cardiac muscle cell differentiation]	613	68.1	No	0
FOXP1-014	ENSP00000318721 ENST00000318779	Q9H334 Show all » « Hide Q9H334 [Direct mapping] Forkhead box protein P1	Show » « Hide Transcription factors Mutated genes in cancer Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001701 [in utero embryonic development] GO:0002053 [positive regulation of mesenchymal cell proliferation] GO:0002329 [pre-B cell differentiation] GO:0002639 [positive regulation of immunoglobulin production] GO:0003682 [chromatin binding] GO:0003690 [double-stranded DNA binding] GO:0003705 [RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity] GO:0005634 [nucleus] GO:0005667 [transcription factor complex] GO:0005737 [cytoplasm] GO:0007389 [pattern specification process] GO:0007519 [skeletal muscle tissue development] GO:0008045 [motor axon guidance] GO:0008134 [transcription factor binding] GO:0008270 [zinc ion binding] GO:0008301 [DNA binding, bending] GO:0009790 [embryo development] GO:0021517 [ventral spinal cord development] GO:0030324 [lung development] GO:0033152 [immunoglobulin V(D)J recombination] GO:0042803 [protein homodimerization activity] GO:0043565 [sequence-specific DNA binding] GO:0045214 [sarcomere organization] GO:0045892 [negative regulation of transcription, DNA-dependent] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046982 [protein heterodimerization activity] GO:0048745 [smooth muscle tissue development] GO:0051090 [regulation of sequence-specific DNA binding transcription factor activity] GO:0055007 [cardiac muscle cell differentiation] GO:0060043 [regulation of cardiac muscle cell proliferation] GO:0060501 [positive regulation of epithelial cell proliferation involved in lung morphogenesis] GO:2000727 [positive regulation of cardiac muscle cell differentiation]	114	12.3	No	0
FOXP1-019	ENSP00000418784 ENST00000497553	C9IYY1 Show all » « Hide C9IYY1 [Target identity:100%; Query identity:100%] Forkhead box protein P1	Show » « Hide Transcription factors Mutated genes in cancer	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001701 [in utero embryonic development] GO:0002053 [positive regulation of mesenchymal cell proliferation] GO:0002329 [pre-B cell differentiation] GO:0002639 [positive regulation of immunoglobulin production] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003705 [RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity] GO:0007519 [skeletal muscle tissue development] GO:0008045 [motor axon guidance] GO:0021517 [ventral spinal cord development] GO:0030324 [lung development] GO:0033152 [immunoglobulin V(D)J recombination] GO:0042803 [protein homodimerization activity] GO:0045214 [sarcomere organization] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046982 [protein heterodimerization activity] GO:0048745 [smooth muscle tissue development] GO:0050679 [positive regulation of epithelial cell proliferation] GO:0055007 [cardiac muscle cell differentiation] GO:0060043 [regulation of cardiac muscle cell proliferation] GO:2000727 [positive regulation of cardiac muscle cell differentiation]	123	14.3	No	0
FOXP1-021	ENSP00000417941 ENST00000485326	C9J5T4 Show all » « Hide C9J5T4 [Target identity:100%; Query identity:100%] Forkhead box protein P1 C9IYY1 [Target identity:54%; Query identity:100%] Forkhead box protein P1	Show » « Hide Transcription factors Mutated genes in cancer	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001701 [in utero embryonic development] GO:0002053 [positive regulation of mesenchymal cell proliferation] GO:0002329 [pre-B cell differentiation] GO:0002639 [positive regulation of immunoglobulin production] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003705 [RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity] GO:0005634 [nucleus] GO:0007519 [skeletal muscle tissue development] GO:0008045 [motor axon guidance] GO:0021517 [ventral spinal cord development] GO:0030324 [lung development] GO:0033152 [immunoglobulin V(D)J recombination] GO:0042803 [protein homodimerization activity] GO:0045214 [sarcomere organization] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046982 [protein heterodimerization activity] GO:0048745 [smooth muscle tissue development] GO:0050679 [positive regulation of epithelial cell proliferation] GO:0055007 [cardiac muscle cell differentiation] GO:0060043 [regulation of cardiac muscle cell proliferation] GO:2000727 [positive regulation of cardiac muscle cell differentiation]	224	25.4	No	0

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.