DGUOK

GENE INFORMATION

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Gene name

DGUOK (HGNC Symbol)

Synonyms

dGK

Description

Deoxyguanosine kinase (HGNC Symbol)

Entrez gene summary

In mammalian cells, the phosphorylation of purine deoxyribonucleosides is mediated predominantly by two deoxyribonucleoside kinases, cytosolic deoxycytidine kinase and mitochondrial deoxyguanosine kinase. The protein encoded by this gene is responsible for phosphorylation of purine deoxyribonucleosides in the mitochondrial matrix. In addition, this protein phosphorylates several purine deoxyribonucleoside analogs used in the treatment of lymphoproliferative disorders, and this phosphorylation is critical for the effectiveness of the analogs. Alternative splice variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Chromosome

2

Cytoband

p13.1

Chromosome location (bp)

74153953 - 74186088

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000114956 (version 75.37)

Entrez gene

1716

UniProt

Q16854 (UniProt - Evidence at protein level)

neXtProt

NX_Q16854

Antibodypedia

DGUOK antibodies
 

PROTEIN VIEW

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DGUOK-001
 
DGUOK-002
 
DGUOK-003
 
DGUOK-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DGUOK-001 ENSP00000264093
ENST00000264093
Q16854
Show all »
Show » Show » 277 32.1 No 0
DGUOK-002 ENSP00000306964
ENST00000348222
Q16854
Show all »
Show » Show » 189 21.4 No 0
DGUOK-003 ENSP00000408209
ENST00000418996
Q7L1W9
Show all »
Show » Show » 89 9.4 No 0
DGUOK-201 ENSP00000349294
ENST00000356837
C9JFV8
Show all »
Show » Show » 255 29.7 No 0