ZAP70

GENE INFORMATION

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Gene name

ZAP70 (HGNC Symbol)

Synonyms

SRK, STD, ZAP-70

Description

zeta-chain (TCR) associated protein kinase 70kDa (HGNC Symbol)

Entrez gene summary

This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

2 (Chromosome progress)

Cytoband

q11.2

Chromosome location (bp)

98330023 - 98356325

Ensembl

ENSG00000115085 (version 73.37)

Entrez gene

7535

UniProt

P43403 (UniProt - Evidence at protein level)

neXtProt

NX_P43403

Antibodypedia

ZAP70 antibodies
 

PROTEIN VIEW

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ZAP70-001
 
ZAP70-008
 
ZAP70-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ZAP70-001 ENSP00000264972
ENST00000264972
P43403
Show all »
Show » Show » 619 69.9 No 0
ZAP70-008 ENSP00000400475
ENST00000451498
P43403
Show all »
Show » Show » 312 35.6 No 0
ZAP70-201 ENSP00000411141
ENST00000442208
P43403
Show all »
Show » Show » 493 55.9 No 0