AUP1

GENE INFORMATION

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Gene name

AUP1

Synonyms

Description

ancient ubiquitous protein 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a protein that contains a domain with homology to the ancient conserved region of the archain 1 gene and a domain that may be involved in binding ubiquitin-conjugating enzymes. The protein encoded by this gene has been shown to bind to the conserved membrane-proximal sequence of the cytoplasmic tail of integrin alpha(IIb) subunits. These subunits play a crucial role in the integrin alpha(IIb)beta(3) inside-out signalling in platelets and megakaryocytes that leads to platelet aggregation and thrombus formation. This gene overlaps the gene for mitochondrial serine protease 25. [provided by RefSeq, Jul 2008]

Chromosome

2 (Chromosome progress)

Cytoband

p13.1

Chromosome location (bp)

74753772 - 74757066

Ensembl

ENSG00000115307 (version 73.37)

Entrez gene

550

UniProt

Q9Y679 (UniProt - Evidence at protein level)

neXtProt

NX_Q9Y679

Antibodypedia

AUP1 antibodies
 

PROTEIN VIEW

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AUP1-001
 
AUP1-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

AUP1-001 ENSP00000366748
ENST00000377526
Q9Y679
Show all »
Show » Show » 410 45.8 No 2
AUP1-002 ENSP00000403430
ENST00000425118
Q9Y679
Show all »
Show » Show » 373 41.4 No 2