MRPL19

GENERAL INFORMATION

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Gene name

MRPL19

Gene description

Mitochondrial ribosomal protein L19

Protein class

Mitochondrial proteins
Plasma proteins
Predicted intracellular proteins
Ribosomal proteins

Predicted localization

Intracellular

Number of transcripts

6
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Normal tissues showed moderate to strong cytoplasmic staining with a granular pattern. Hepatocytes displayed additional membranous staining. Bile duct cells, cells in glomeruli and glial cells were negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA056622
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

MRPL19 (HGNC Symbol)

Synonyms

KIAA0104, MRP-L15, RLX1, RPML15

Description

Mitochondrial ribosomal protein L19 (HGNC Symbol)

Entrez gene summary

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]

Chromosome

2

Cytoband

p12

Chromosome location (bp)

75646783 - 75690851

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000115364 (version 78.38)

Entrez gene

9801

UniProt

P49406 (UniProt - Evidence at protein level)

neXtProt

NX_P49406

Antibodypedia

MRPL19 antibodies


PROTEIN BROWSER

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ENST00000358788
 
ENST00000393909
 
ENST00000409374
 
ENST00000453233
 
ENST00000476622
 
ENST00000492255
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MRPL19-001 ENSP00000377486
ENST00000393909
P49406
Show all »
Show » Show » 292 33.5 No 0
MRPL19-002 ENSP00000387284
ENST00000409374
P49406
Show all »
Show » Show » 292 33.5 No 0
MRPL19-004 ENSP00000474821
ENST00000476622
S4R3W9
Show all »
Show » Show » 143 16.6 No 0
MRPL19-005 ENSP00000351639
ENST00000358788
Show » Show » 173 19.1 No 0
MRPL19-006 ENSP00000406267
ENST00000453233
H7C2J0
Show all »
Show » Show » 79 9.7 No 0
MRPL19-007 ENSP00000475090
ENST00000492255
Show » 58 6.5 No 0