The cancer tissue page shows antibody staining in 20 different cancers. The overall cancer tissue staining statistics shows the fraction of patient samples with strong, moderate, weak or no staining (as described by the color-coding scale in the box to the right), using all the available antibodies to the protein targets encoded by this gene. The assay and annotation is described here.
The cancers can be ordered histologically or alphabetically.
For each cancer, the staining for each available antibody is reported as the fraction of samples with strong, moderate, weak or no staining (as described by the color-coding scale in the box to the right). The lenght of the bar represents the number of patient samples analysed (max=12 patients). By clicking on a cancer tissue, the detailed staining data for that cancer is available, including annotated images.
At the bottom of this page, a summary for the cancer staining for each antibody is given, together with the immunohistochemistry validation score for that antibody.
Most malignant tissues exhibited moderate cytoplasmic and membranous positivity. Malignant gliomas were weakly stained or negative.
Moderate to strong cytoplasmic positivity was observed in colorectal, breast and ovarian cancer as well as a few cases of cervical, endometrial and liver cancers. Prostate cancer and several cases of pancreatic, gastric, testicular, urothelial and thyroid cancer were moderately stained. Remaining malignant cells were weakly stained or negative.
A majority of cancers displayed weak to moderate cytoplasmic and sometimes nucleolar positivity. Thyroid cancers and a few colorectal and prostate cancers were strongly stained.
Validation
Two (or more) antibodies yielding partly similar staining patterns which are partly consistent with gene/protein characterization data or consistent with limited gene/protein characterization data
Two (or more) antibodies yielding partly similar staining patterns which are partly consistent with gene/protein characterization data or consistent with limited gene/protein characterization data
Two (or more) antibodies yielding partly similar staining patterns which are partly consistent with gene/protein characterization data or consistent with limited gene/protein characterization data
