The cancer tissue page shows antibody staining in 20 different cancers. The overall cancer tissue staining statistics shows the fraction of patient samples with strong, moderate, weak or no staining (as described by the color-coding scale in the box to the right), using all the available antibodies to the protein targets encoded by this gene. The assay and annotation is described here.
The cancers can be ordered histologically or alphabetically.
For each cancer, the staining for each available antibody is reported as the fraction of samples with strong, moderate, weak or no staining (as described by the color-coding scale in the box to the right). The lenght of the bar represents the number of patient samples analysed (max=12 patients). By clicking on a cancer tissue, the detailed staining data for that cancer is available, including annotated images.
At the bottom of this page, a summary for the cancer staining for each antibody is given, together with the immunohistochemistry validation score for that antibody.
Malignant lymphomas, gliomas, melanomas, testis, urothelial, renal, stomach, cervical and breast cancers showed cases of moderate to strong cytoplasmic and nuclear positivity. Remaining malignancies were generally weakly stained or negative.
Some renal, gastric, cervical, ovarian and breast cancers were strongly stained in nuclei and cytoplasm. Inflammatory cells, endothelial cells and fibroblasts in the tumour stroma were often positive. Remaining malignant tissues were in general negative.
Selected cases of most malignancies showed moderate to strong cytoplasmic positivity. Prostate, endometrial, thyroid, liver cancer and malignant carcinoid were mainly negative.
Validation
Two (or more) antibodies yielding partly similar staining patterns which are consistent with gene/protein characterization data
Two (or more) antibodies yielding partly similar staining patterns which are consistent with gene/protein characterization data
Two (or more) antibodies yielding partly similar staining patterns which are partly consistent with gene/protein characterization data or consistent with limited gene/protein characterization data
