STAT1

GENE INFORMATION

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Gene name

STAT1 (HGNC Symbol)

Synonyms

ISGF-3, STAT91

Description

signal transducer and activator of transcription 1, 91kDa (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

Chromosome

2 (Chromosome progress)

Cytoband

q32.2

Chromosome location (bp)

191829084 - 191885686

Ensembl

ENSG00000115415 (version 73.37)

Entrez gene

6772

UniProt

P42224 (UniProt - Evidence at protein level)

neXtProt

NX_P42224

Antibodypedia

STAT1 antibodies
 

PROTEIN VIEW

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 « 
 
STAT1-001
 
STAT1-002
 
STAT1-003
 
STAT1-004
 
STAT1-005
 
STAT1-006
 
STAT1-007
 
STAT1-008
 
STAT1-010
 
STAT1-011
 
STAT1-201
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

STAT1-001 ENSP00000354394
ENST00000361099
P42224
Show all »
Show » Show » 750 87.3 No 0
STAT1-002 ENSP00000376137
ENST00000392323
J3KPM9
Show all »
Show » Show » 714 83.4 No 0
STAT1-003 ENSP00000376136
ENST00000392322
P42224
Show all »
Show » Show » 712 83 No 0
STAT1-004 ENSP00000402548
ENST00000424722
E7EPD2
Show all »
Show » Show » 180 21.8 No 0
STAT1-005 ENSP00000388772
ENST00000423282
58 6.4 No 0
STAT1-006 ENSP00000394512
ENST00000452281
D2KFR9
Show all »
Show » Show » 193 23.1 No 0
STAT1-007 ENSP00000416019
ENST00000432058
E9PH66
Show all »
Show » Show » 70 8.6 No 0
STAT1-008 ENSP00000411398
ENST00000454414
E7ENM1
Show all »
Show » Show » 150 18.1 No 0
STAT1-010 ENSP00000388240
ENST00000415035
Show » 40 4.4 No 0
STAT1-011 ENSP00000386244
ENST00000409465
P42224
Show all »
Show » Show » 750 87.3 No 0
STAT1-201 ENSP00000438703
ENST00000540176
D2KFR9
Show all »
Show » Show » 193 23.1 No 0