GNLY

GENE INFORMATION

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Gene name

GNLY (HGNC Symbol)

Synonyms

D2S69E, LAG-2, LAG2, NKG5, TLA519

Description

granulysin (HGNC Symbol)

Entrez gene summary

The product of this gene is a member of the saposin-like protein (SAPLIP) family and is located in the cytotoxic granules of T cells, which are released upon antigen stimulation. This protein is present in cytotoxic granules of cytotoxic T lymphocytes and natural killer cells, and it has antimicrobial activity against M. tuberculosis and other organisms. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Chromosome

2 (Chromosome progress)

Cytoband

p11.2

Chromosome location (bp)

85912298 - 85925977

Ensembl

ENSG00000115523 (version 73.37)

Entrez gene

10578

UniProt

P22749 (UniProt - Evidence at protein level)

neXtProt

NX_P22749

Antibodypedia

GNLY antibodies
 

PROTEIN VIEW

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GNLY-001
 
GNLY-008
 
GNLY-010
 
GNLY-014
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GNLY-001 ENSP00000263863
ENST00000263863
P22749
Show all »
Show » Show » 145 16.4 Yes 0
GNLY-008 ENSP00000387116
ENST00000409696
P22749
Show all »
Show » Show » 130 14.9 No 0
GNLY-010 ENSP00000436423
ENST00000524600
B4E3H9
Show all »
172 19.3 Yes 0
GNLY-014 ENSP00000434467
ENST00000526018
187 20.8 No 0