AAK1

GENERAL INFORMATION

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Gene name

AAK1

Gene description

AP2 associated kinase 1

Protein class

Enzymes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

7
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Tissue enhanced (cerebellum, cerebral cortex)

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression at variable levels in several different cell types.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Data reliability

Uncertain based on 2 antibodies.
HPA017931 , HPA020289
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (cerebellum, cerebral cortex)

Organ

Expression



GENE INFORMATION

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Gene name

AAK1 (HGNC Symbol)

Synonyms

DKFZp686K16132, KIAA1048

Description

AP2 associated kinase 1 (HGNC Symbol)

Entrez gene summary

Adaptor-related protein complex 2 (AP-2 complexes) functions during receptor-mediated endocytosis to trigger clathrin assembly, interact with membrane-bound receptors, and recruit encodytic accessory factors. This gene encodes a member of the SNF1 subfamily of Ser/Thr protein kinases. The protein interacts with and phosphorylates a subunit of the AP-2 complex, which promotes binding of AP-2 to sorting signals found in membrane-bound receptors and subsequent receptor endocytosis. Its kinase activity is stimulated by clathrin. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

Chromosome

2

Cytoband

p13.3

Chromosome location (bp)

69457995 - 69674349

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000115977 (version 78.38)

Entrez gene

22848

UniProt

Q2M2I8 (UniProt - Evidence at protein level)

neXtProt

NX_Q2M2I8

Antibodypedia

AAK1 antibodies


PROTEIN BROWSER

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ENST00000339092
 
ENST00000406297
 
ENST00000409068
 
ENST00000409085
 
ENST00000606389
 
ENST00000623317
 
ENST00000624900
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

AAK1-001 ENSP00000386456
ENST00000409085
Q2M2I8
Show all »
Show » Show » 961 103.9 No 0
AAK1-002 ENSP00000385181
ENST00000406297
Q2M2I8
Show all »
Show » Show » 863 93.6 No 0
AAK1-011 ENSP00000386342
ENST00000409068
E9PG46
Show all »
Show » Show » 674 73.8 No 0
AAK1-012 ENSP00000485350
ENST00000606389
L0R804
Show all »
Show » 511 54.4 No 0
AAK1-013 ENSP00000485296
ENST00000623317
Show » 340 36.4 No 0
AAK1-014 ENSP00000485409
ENST00000624900
Show » 99 10.3 No 0
AAK1-201 ENSP00000478720
ENST00000339092
Show » Show » 789 85.8 No 0