AAK1

GENE INFORMATION

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Gene name

AAK1 (HGNC Symbol)

Synonyms

DKFZp686K16132, KIAA1048

Description

AP2 associated kinase 1 (HGNC Symbol)

Entrez gene summary

Adaptor-related protein complex 2 (AP-2 complexes) functions during receptor-mediated endocytosis to trigger clathrin assembly, interact with membrane-bound receptors, and recruit encodytic accessory factors. This gene encodes a member of the SNF1 subfamily of Ser/Thr protein kinases. The protein interacts with and phosphorylates a subunit of the AP-2 complex, which promotes binding of AP-2 to sorting signals found in membrane-bound receptors and subsequent receptor endocytosis. Its kinase activity is stimulated by clathrin. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

Chromosome

2 (Chromosome progress)

Cytoband

p13.3

Chromosome location (bp)

69688532 - 69901481

Ensembl

ENSG00000115977 (version 73.37)

Entrez gene

22848

UniProt

Q2M2I8 (UniProt - Evidence at protein level)

neXtProt

NX_Q2M2I8

Antibodypedia

AAK1 antibodies
 

PROTEIN VIEW

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AAK1-001
 
AAK1-002
 
AAK1-011
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

AAK1-001 ENSP00000386456
ENST00000409085
Q2M2I8
Show all »
Show » Show » 961 103.9 No 0
AAK1-002 ENSP00000385181
ENST00000406297
Q2M2I8
Show all »
Show » Show » 863 93.6 No 0
AAK1-011 ENSP00000386342
ENST00000409068
E9PG46
Show all »
Show » Show » 674 73.8 No 0