KCNC4

GENERAL INFORMATION

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Gene name

KCNC4

Gene description

Potassium voltage-gated channel, Shaw-related subfamily, member 4

Protein class

Predicted membrane proteins
Voltage-gated ion channels

Predicted localization

Membrane

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Mixed
GTEx:Mixed

Protein evidence

Evidence at protein level

Protein localization

Most of the normal tissues displayed moderate cytoplasmic positivity. Strong staining was observed in adrenal cortical cells, skeletal muscle, thyroid gland and in occasional neuronal cells. Squamous epithelia were weakly stained.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA014740
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Adrenal gland

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Mixed

Organ

Expression

GTEx dataset
RNA tissue category:  Mixed

Organ

Expression



GENE INFORMATION

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Gene name

KCNC4 (HGNC Symbol)

Synonyms

C1orf30, HKSHIIIC, Kv3.4

Description

Potassium voltage-gated channel, Shaw-related subfamily, member 4 (HGNC Symbol)

Entrez gene summary

The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. It generates atypical voltage-dependent transient current that may be important for neuronal excitability. Multiple transcript variants have been found for this gene. [provided by RefSeq, Jul 2010]

Chromosome

1

Cytoband

p13.3

Chromosome location (bp)

110211343 - 110283100

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000116396 (version 78.38)

Entrez gene

3749

UniProt

Q03721 (UniProt - Evidence at protein level)

neXtProt

NX_Q03721

Antibodypedia

KCNC4 antibodies


PROTEIN BROWSER

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ENST00000369787
 
ENST00000413138
 
ENST00000438661
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

KCNC4-003 ENSP00000393655
ENST00000438661
Q03721
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Show » Show » 626 68.8 No 7
KCNC4-004 ENSP00000358802
ENST00000369787
Q03721
Show all »
Show » Show » 635 69.8 No 7
KCNC4-006 ENSP00000388029
ENST00000413138
H7BZ66
Show all »
Show » Show » 624 68.5 No 7