NCF2

GENE INFORMATION

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Gene name

NCF2 (HGNC Symbol)

Synonyms

NOXA2, p67phox

Description

Neutrophil cytosolic factor 2 (HGNC Symbol)

Entrez gene summary

This gene encodes neutrophil cytosolic factor 2, the 67-kilodalton cytosolic subunit of the multi-protein NADPH oxidase complex found in neutrophils. This oxidase produces a burst of superoxide which is delivered to the lumen of the neutrophil phagosome. Mutations in this gene, as well as in other NADPH oxidase subunits, can result in chronic granulomatous disease, a disease that causes recurrent infections by catalase-positive organisms. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2010]

Chromosome

1

Cytoband

q25.3

Chromosome location (bp)

183524698 - 183560011

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000116701 (version 75.37)

Entrez gene

4688

UniProt

P19878 (UniProt - Evidence at protein level)

neXtProt

NX_P19878

Antibodypedia

NCF2 antibodies
 

PROTEIN VIEW

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NCF2-001
 
NCF2-002
 
NCF2-004
 
NCF2-005
 
NCF2-201
 
NCF2-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NCF2-001 ENSP00000356506
ENST00000367536
P19878
Show all »
Show » Show » 526 59.8 No 0
NCF2-002 ENSP00000356505
ENST00000367535
P19878
Show all »
Show » Show » 526 59.8 No 0
NCF2-004 ENSP00000406198
ENST00000419402
B1ALB7
Show all »
Show » Show » 143 16.2 No 0
NCF2-005 ENSP00000397228
ENST00000420553
B1ALB6
Show all »
Show » Show » 56 6.7 No 0
NCF2-201 ENSP00000399294
ENST00000413720
P19878
Show all »
Show » Show » 481 54.4 No 0
NCF2-202 ENSP00000407217
ENST00000418089
P19878
Show all »
Show » Show » 445 50.3 No 0