NCF2

GENERAL INFORMATION

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Gene name

NCF2

Gene description

Neutrophil cytosolic factor 2

Protein class

Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

6
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Tissue enhanced (lung, spleen)

Protein evidence

Evidence at protein level

Protein localization

High and selective cytoplasmic and nuclear expression in neutrophils and macrophages.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 3 antibodies.
HPA002327 , HPA006040 , CAB022160
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Spleen

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (lung, spleen)

Organ

Expression



GENE INFORMATION

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Gene name

NCF2 (HGNC Symbol)

Synonyms

NOXA2, p67phox

Description

Neutrophil cytosolic factor 2 (HGNC Symbol)

Entrez gene summary

This gene encodes neutrophil cytosolic factor 2, the 67-kilodalton cytosolic subunit of the multi-protein NADPH oxidase complex found in neutrophils. This oxidase produces a burst of superoxide which is delivered to the lumen of the neutrophil phagosome. Mutations in this gene, as well as in other NADPH oxidase subunits, can result in chronic granulomatous disease, a disease that causes recurrent infections by catalase-positive organisms. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2010]

Chromosome

1

Cytoband

q25.3

Chromosome location (bp)

183555563 - 183590876

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000116701 (version 78.38)

Entrez gene

4688

UniProt

P19878 (UniProt - Evidence at protein level)

neXtProt

NX_P19878

Antibodypedia

NCF2 antibodies


PROTEIN BROWSER

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ENST00000367535
 
ENST00000367536
 
ENST00000413720
 
ENST00000418089
 
ENST00000419402
 
ENST00000420553
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NCF2-001 ENSP00000356506
ENST00000367536
P19878
Show all »
Show » Show » 526 59.8 No 0
NCF2-002 ENSP00000356505
ENST00000367535
P19878
Show all »
Show » Show » 526 59.8 No 0
NCF2-004 ENSP00000406198
ENST00000419402
B1ALB7
Show all »
Show » Show » 143 16.2 No 0
NCF2-005 ENSP00000397228
ENST00000420553
B1ALB6
Show all »
Show » Show » 56 6.7 No 0
NCF2-201 ENSP00000399294
ENST00000413720
P19878
Show all »
Show » Show » 481 54.4 No 0
NCF2-202 ENSP00000407217
ENST00000418089
P19878
Show all »
Show » Show » 445 50.3 No 0