MRPS15

GENE INFORMATION

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Gene name

MRPS15 (HGNC Symbol)

Synonyms

FLJ11564

Description

mitochondrial ribosomal protein S15 (HGNC Symbol)

Entrez gene summary

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S15P family. The encoded protein is more than two times the size of its E. coli counterpart, with the 12S rRNA binding sites conserved. Between human and mouse, the encoded protein is the least conserved among small subunit ribosomal proteins. Pseudogenes corresponding to this gene are found on chromosomes 15q and 19q. [provided by RefSeq, Jul 2008]

Chromosome

1 (Chromosome progress)

Cytoband

p34.3

Chromosome location (bp)

36921319 - 36930038

Ensembl

ENSG00000116898 (version 73.37)

Entrez gene

64960

UniProt

P82914 (UniProt - Evidence at protein level)

neXtProt

NX_P82914

Antibodypedia

MRPS15 antibodies
 

PROTEIN VIEW

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MRPS15-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MRPS15-001 ENSP00000362208
ENST00000373116
P82914
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