SDHB

GENE INFORMATION

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Gene name

SDHB (HGNC Symbol)

Synonyms

SDH, SDH1

Description

succinate dehydrogenase complex, subunit B, iron sulfur (Ip) (HGNC Symbol)

Entrez gene summary

Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis. [provided by RefSeq, Jul 2008]

Chromosome

1 (Chromosome progress)

Cytoband

p36.13

Chromosome location (bp)

17345217 - 17380665

Ensembl

ENSG00000117118 (version 73.37)

Entrez gene

6390

UniProt

P21912 (UniProt - Evidence at protein level)

neXtProt

NX_P21912

Antibodypedia

SDHB antibodies
 

PROTEIN VIEW

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SDHB-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SDHB-001 ENSP00000364649
ENST00000375499
P21912
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