CD160

GENE INFORMATION

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Gene name

CD160 (HGNC Symbol)

Synonyms

BY55, NK1, NK28

Description

CD160 molecule (HGNC Symbol)

Entrez gene summary

CD160 is an 27 kDa glycoprotein which was initially identified with the monoclonal antibody BY55. Its expression is tightly associated with peripheral blood NK cells and CD8 T lymphocytes with cytolytic effector activity. The cDNA sequence of CD160 predicts a cysteine-rich, glycosylphosphatidylinositol-anchored protein of 181 amino acids with a single Ig-like domain weakly homologous to KIR2DL4 molecule. CD160 is expressed at the cell surface as a tightly disulfide-linked multimer. RNA blot analysis revealed CD160 mRNAs of 1.5 and 1.6 kb whose expression was highly restricted to circulating NK and T cells, spleen and small intestine. Within NK cells CD160 is expressed by CD56dimCD16+ cells whereas among circulating T cells its expression is mainly restricted to TCRgd bearing cells and to TCRab+CD8brightCD95+CD56+CD28-CD27-cells. In tissues, CD160 is expressed on all intestinal intraepithelial lymphocytes. CD160 shows a broad specificity for binding to both classical and nonclassical MHC class I molecules. [provided by RefSeq, Jul 2008]

Chromosome

1 (Chromosome progress)

Cytoband

q21.1

Chromosome location (bp)

145695798 - 145715614

Ensembl

ENSG00000117281 (version 73.37)

Entrez gene

11126

UniProt

O95971 (UniProt - Evidence at transcript level)

neXtProt

NX_O95971

Antibodypedia

CD160 antibodies
 

PROTEIN VIEW

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CD160-006
 
CD160-007
 
CD160-201
 
CD160-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CD160-006 ENSP00000358294
ENST00000369288
O95971
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Show » Show » 181 19.8 Yes 0
CD160-007 ENSP00000358296
ENST00000369290
Q5T2V6
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Show » 125 14 Yes 0
CD160-201 ENSP00000235933
ENST00000235933
O95971
Show all »
Show » Show » 181 19.8 Yes 0
CD160-202 ENSP00000385199
ENST00000401557
O95971
Show all »
Show » Show » 181 19.8 Yes 0