MPL

GENE INFORMATION

? »

Gene name

MPL (HGNC Symbol)

Synonyms

CD110, TPOR

Description

myeloproliferative leukemia virus oncogene (HGNC Symbol)

Entrez gene summary

In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl, thrombopoietin, was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated. [provided by RefSeq, Jul 2008]

Chromosome

1 (Chromosome progress)

Cytoband

p34.2

Chromosome location (bp)

43803478 - 43818443

Ensembl

ENSG00000117400 (version 73.37)

Entrez gene

4352

UniProt

P40238 (UniProt - Evidence at protein level)

neXtProt

NX_P40238

Antibodypedia

MPL antibodies
 

PROTEIN VIEW

? »
 
 
 
MPL-001
 
MPL-002
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MPL-001 ENSP00000361548
ENST00000372470
P40238
Show all »
Show » Show » 635 71.2 Yes 1
MPL-002 ENSP00000414004
ENST00000413998
Q5JUY5
Show all »
Show » Show » 549 62.2 Yes 1