ATP6V0B

GENE INFORMATION

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Gene name

ATP6V0B (HGNC Symbol)

Synonyms

ATP6F, HATPL, VMA16

Description

ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b (HGNC Symbol)

Entrez gene summary

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is part of the transmembrane V0 domain and is the human counterpart of yeast VMA16. Two alternatively spliced transcript variants that encode different proteins have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

1 (Chromosome progress)

Cytoband

p34.1

Chromosome location (bp)

44440159 - 44443967

Ensembl

ENSG00000117410 (version 73.37)

Entrez gene

533

UniProt

Q99437 (UniProt - Evidence at transcript level)

neXtProt

NX_Q99437

Antibodypedia

ATP6V0B antibodies
 

PROTEIN VIEW

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ATP6V0B-001
 
ATP6V0B-004
 
ATP6V0B-006
 
ATP6V0B-007
 
ATP6V0B-009
 
ATP6V0B-011
 
ATP6V0B-012
 
ATP6V0B-013
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ATP6V0B-001 ENSP00000431605
ENST00000472174
Q99437
Show all »
Show » Show » 205 21.4 No 5
ATP6V0B-004 ENSP00000236067
ENST00000236067
Q99437
Show all »
Show » Show » 158 16.2 No 3
ATP6V0B-006 ENSP00000432754
ENST00000471859
E9PNU0
Show all »
Show » Show » 252 26.1 Yes 4
ATP6V0B-007 ENSP00000431375
ENST00000498208
88 9.2 No 0
ATP6V0B-009 ENSP00000435396
ENST00000461670
E9PKB6
Show all »
Show » 46 4.6 No 0
ATP6V0B-011 ENSP00000434094
ENST00000498664
Q99437
Show all »
Show » Show » 158 16.2 No 3
ATP6V0B-012 ENSP00000434729
ENST00000532642
E9PNL3
Show all »
Show » Show » 261 27.7 No 5
ATP6V0B-013 ENSP00000432994
ENST00000472505
E9PMR1
Show all »
Show » Show » 86 9 No 2