F3

GENE INFORMATION

? »

Gene name

F3 (HGNC Symbol)

Synonyms

CD142

Description

coagulation factor III (thromboplastin, tissue factor) (HGNC Symbol)

Entrez gene summary

This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

Chromosome

1 (Chromosome progress)

Cytoband

p21.3

Chromosome location (bp)

94994781 - 95007356

Ensembl

ENSG00000117525 (version 73.37)

Entrez gene

2152

UniProt

P13726 (UniProt - Evidence at protein level)

neXtProt

NX_P13726

Antibodypedia

F3 antibodies
 

PROTEIN VIEW

? »
 
 
 
F3-001
 
F3-002
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

F3-001 ENSP00000334145
ENST00000334047
P13726
Show all »
Show » Show » 295 33.1 No 1
F3-002 ENSP00000359226
ENST00000370207
P13726
Show all »
Show » Show » 238 27.1 No 0