CTSD

GENE INFORMATION

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Gene name

CTSD (HGNC Symbol)

Synonyms

CLN10, CPSD

Description

cathepsin D (HGNC Symbol)

Entrez gene summary

This gene encodes a lysosomal aspartyl protease composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. This proteinase, which is a member of the peptidase C1 family, has a specificity similar to but narrower than that of pepsin A. Transcription of this gene is initiated from several sites, including one which is a start site for an estrogen-regulated transcript. Mutations in this gene are involved in the pathogenesis of several diseases, including breast cancer and possibly Alzheimer disease. [provided by RefSeq, Jul 2008]

Chromosome

11 (Chromosome progress)

Cytoband

p15.5

Chromosome location (bp)

1773982 - 1785222

Ensembl

ENSG00000117984 (version 73.37)

Entrez gene

1509

UniProt

P07339 (UniProt - Evidence at protein level)

neXtProt

NX_P07339

Antibodypedia

CTSD antibodies
 

PROTEIN VIEW

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CTSD-001
 
CTSD-002
 
CTSD-004
 
CTSD-005
 
CTSD-006
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CTSD-001 ENSP00000236671
ENST00000236671
P07339
Show all »
Show » Show » 412 44.6 Yes 0
CTSD-002 ENSP00000356164
ENST00000367196
F8W787
Show all »
Show » 199 21.5 No 0
CTSD-004 ENSP00000402586
ENST00000429746
H7C1V0
Show all »
Show » 189 20.4 No 0
CTSD-005 ENSP00000415036
ENST00000438213
C9JH19
Show all »
Show » 299 32.6 No 0
CTSD-006 ENSP00000404902
ENST00000433655
F8WD96
Show all »
Show » Show » 276 30 Yes 0