STK11

GENE INFORMATION

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Gene name

STK11 (HGNC Symbol)

Synonyms

LKB1, PJS

Description

serine/threonine kinase 11 (HGNC Symbol)

Entrez gene summary

This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]

Chromosome

19 (Chromosome progress)

Cytoband

p13.3

Chromosome location (bp)

1189406 - 1228428

Ensembl

ENSG00000118046 (version 73.37)

Entrez gene

6794

UniProt

Q15831 (UniProt - Evidence at protein level)

neXtProt

NX_Q15831

Antibodypedia

STK11 antibodies
 

PROTEIN VIEW

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STK11-001
 
STK11-004
 
STK11-008
 
STK11-009
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

STK11-001 ENSP00000324856
ENST00000326873
Q15831
Show all »
Show » Show » 433 48.6 No 0
STK11-004 ENSP00000467912
ENST00000585851
K7EQN8
Show all »
Show » Show » 153 17.1 No 0
STK11-008 ENSP00000466610
ENST00000593219
K7EMR0
Show all »
Show » Show » 101 11.6 No 0
STK11-009 ENSP00000467240
ENST00000586243
Show » Show » 282 30.2 No 0