APOA1

GENE INFORMATION

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Gene name

APOA1

Synonyms

Description

apolipoprotein A-I (HGNC Symbol)

Entrez gene summary

This gene encodes apolipoprotein A-I, which is the major protein component of high density lipoprotein (HDL) in plasma. The protein promotes cholesterol efflux from tissues to the liver for excretion, and it is a cofactor for lecithin cholesterolacyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. This gene is closely linked with two other apolipoprotein genes on chromosome 11. Defects in this gene are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis. [provided by RefSeq, Jul 2008]

Chromosome

11 (Chromosome progress)

Cytoband

q23.3

Chromosome location (bp)

116706467 - 116708666

Ensembl

ENSG00000118137 (version 73.37)

Entrez gene

335

UniProt

P02647 (UniProt - Evidence at protein level)

neXtProt

NX_P02647

Antibodypedia

APOA1 antibodies
 

PROTEIN VIEW

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APOA1-001
 
APOA1-002
 
APOA1-003
 
APOA1-004
 
APOA1-005
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

APOA1-001 ENSP00000236850
ENST00000236850
P02647
Show all »
Show » Show » 267 30.8 Yes 0
APOA1-002 ENSP00000364469
ENST00000375320
P02647
Show all »
Show » Show » 267 30.8 Yes 0
APOA1-003 ENSP00000364472
ENST00000375323
P02647
Show all »
Show » Show » 267 30.8 Yes 0
APOA1-004 ENSP00000352471
ENST00000359492
P02647
Show all »
Show » Show » 267 30.8 Yes 0
APOA1-005 ENSP00000364478
ENST00000375329
F8W696
Show all »
Show » 245 27.9 No 0