ATF6

GENE INFORMATION

? »

Gene name

ATF6 (HGNC Symbol)

Synonyms

ATF6A

Description

activating transcription factor 6 (HGNC Symbol)

Entrez gene summary

This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis. [provided by RefSeq, Aug 2011]

Chromosome

1 (Chromosome progress)

Cytoband

q23.3

Chromosome location (bp)

161736084 - 161933860

Ensembl

ENSG00000118217 (version 73.37)

Entrez gene

22926

UniProt

P18850 (UniProt - Evidence at protein level)

neXtProt

NX_P18850

Antibodypedia

ATF6 antibodies
 

PROTEIN VIEW

? »
 
 
 
ATF6-001
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ATF6-001 ENSP00000356919
ENST00000367942
P18850
Show all »
Show » Show » 670 74.6 No 1