The Human Protein Atlas

Gene name

CNR1 (HGNC Symbol)

Synonyms

CANN6, CB-R, CB1, CB1A, CB1K5, CNR

Description

cannabinoid receptor 1 (brain) (HGNC Symbol)

Entrez gene summary

This gene encodes one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the guanine-nucleotide-binding protein (G-protein) coupled receptor family, which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Multiple transcript variants encoding two different protein isoforms have been described for this gene. [provided by RefSeq, May 2009]

Chromosome

6 (Chromosome progress)

Cytoband

q15

Chromosome location (bp)

88849583 - 88876078

Ensembl

ENSG00000118432 (version 69.37)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CNR1-001

ENSP00000358513
ENST00000369501

P21554
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P21554 [Direct mapping]
Cannabinoid receptor 1
Q9BYY6 [Target identity:69%; Query identity:100%]
Cannabinoid receptor 1
F8W187 [Target identity:16%; Query identity:100%]
Cannabinoid receptor 1

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Transporters
G-protein coupled receptors
   GPCRs excl olfactory receptors
Potential transmembrane proteins
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   7TM proteins predicted by MDM
Mapped to UniProt SWISS-PROT
   UniProt - Evidence at protein level

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GO:0002866 [positive regulation of acute inflammatory response to antigenic stimulus]
GO:0004949 [cannabinoid receptor activity]
GO:0005515 [protein binding]
GO:0005792 [microsome]
GO:0005886 [plasma membrane]
GO:0005887 [integral to plasma membrane]
GO:0006950 [response to stress]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger]
GO:0007188 [G-protein signaling, coupled to cAMP nucleotide second messenger]
GO:0007283 [spermatogenesis]
GO:0007568 [aging]
GO:0007584 [response to nutrient]
GO:0007610 [behavior]
GO:0007611 [learning or memory]
GO:0007613 [memory]
GO:0008144 [drug binding]
GO:0010976 [positive regulation of neuron projection development]
GO:0016021 [integral to membrane]
GO:0019216 [regulation of lipid metabolic process]
GO:0019233 [sensory perception of pain]
GO:0031622 [positive regulation of fever generation]
GO:0031999 [negative regulation of fatty acid beta-oxidation]
GO:0032228 [regulation of synaptic transmission, GABAergic]
GO:0032496 [response to lipopolysaccharide]
GO:0033004 [negative regulation of mast cell activation]
GO:0033602 [negative regulation of dopamine secretion]
GO:0035094 [response to nicotine]
GO:0038171 [cannabinoid signaling pathway]
GO:0042220 [response to cocaine]
GO:0043065 [positive regulation of apoptotic process]
GO:0043271 [negative regulation of ion transport]
GO:0043278 [response to morphine]
GO:0045471 [response to ethanol]
GO:0045759 [negative regulation of action potential]
GO:0045776 [negative regulation of blood pressure]
GO:0045777 [positive regulation of blood pressure]
GO:0050796 [regulation of insulin secretion]
GO:0051001 [negative regulation of nitric-oxide synthase activity]
GO:0051966 [regulation of synaptic transmission, glutamatergic]
GO:0060135 [maternal process involved in female pregnancy]
GO:0060259 [regulation of feeding behavior]
GO:0060405 [regulation of penile erection]

472

52.9

CNR1-002

ENSP00000446819
ENST00000549890

P21554
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P21554 [Direct mapping]
Cannabinoid receptor 1
Q9BYY6 [Target identity:69%; Query identity:100%]
Cannabinoid receptor 1
F8W187 [Target identity:16%; Query identity:100%]
Cannabinoid receptor 1

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GO:0002866 [positive regulation of acute inflammatory response to antigenic stimulus]
GO:0004949 [cannabinoid receptor activity]
GO:0005792 [microsome]
GO:0005886 [plasma membrane]
GO:0005887 [integral to plasma membrane]
GO:0006950 [response to stress]
GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger]
GO:0007188 [G-protein signaling, coupled to cAMP nucleotide second messenger]
GO:0007283 [spermatogenesis]
GO:0007568 [aging]
GO:0007584 [response to nutrient]
GO:0007610 [behavior]
GO:0007613 [memory]
GO:0008144 [drug binding]
GO:0010976 [positive regulation of neuron projection development]
GO:0016021 [integral to membrane]
GO:0019233 [sensory perception of pain]
GO:0031622 [positive regulation of fever generation]
GO:0031999 [negative regulation of fatty acid beta-oxidation]
GO:0032228 [regulation of synaptic transmission, GABAergic]
GO:0032496 [response to lipopolysaccharide]
GO:0033004 [negative regulation of mast cell activation]
GO:0033602 [negative regulation of dopamine secretion]
GO:0035094 [response to nicotine]
GO:0038171 [cannabinoid signaling pathway]
GO:0042220 [response to cocaine]
GO:0043065 [positive regulation of apoptotic process]
GO:0043271 [negative regulation of ion transport]
GO:0043278 [response to morphine]
GO:0045471 [response to ethanol]
GO:0045759 [negative regulation of action potential]
GO:0045776 [negative regulation of blood pressure]
GO:0045777 [positive regulation of blood pressure]
GO:0050796 [regulation of insulin secretion]
GO:0051001 [negative regulation of nitric-oxide synthase activity]
GO:0051966 [regulation of synaptic transmission, glutamatergic]
GO:0060135 [maternal process involved in female pregnancy]
GO:0060259 [regulation of feeding behavior]
GO:0060405 [regulation of penile erection]

472

52.9

CNR1-003

ENSP00000355418
ENST00000362094

F8W908
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F8W908 [Target identity:100%; Query identity:100%]
Cannabinoid receptor 1

CNR1-004

ENSP00000420188
ENST00000468898

P21554
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P21554 [Direct mapping]
Cannabinoid receptor 1

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GO:0002866 [positive regulation of acute inflammatory response to antigenic stimulus]
GO:0004949 [cannabinoid receptor activity]
GO:0005792 [microsome]
GO:0005886 [plasma membrane]
GO:0005887 [integral to plasma membrane]
GO:0006950 [response to stress]
GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger]
GO:0007188 [G-protein signaling, coupled to cAMP nucleotide second messenger]
GO:0007283 [spermatogenesis]
GO:0007568 [aging]
GO:0007584 [response to nutrient]
GO:0007610 [behavior]
GO:0007613 [memory]
GO:0008144 [drug binding]
GO:0010976 [positive regulation of neuron projection development]
GO:0019233 [sensory perception of pain]
GO:0031622 [positive regulation of fever generation]
GO:0031999 [negative regulation of fatty acid beta-oxidation]
GO:0032228 [regulation of synaptic transmission, GABAergic]
GO:0032496 [response to lipopolysaccharide]
GO:0033004 [negative regulation of mast cell activation]
GO:0033602 [negative regulation of dopamine secretion]
GO:0035094 [response to nicotine]
GO:0038171 [cannabinoid signaling pathway]
GO:0042220 [response to cocaine]
GO:0043065 [positive regulation of apoptotic process]
GO:0043271 [negative regulation of ion transport]
GO:0043278 [response to morphine]
GO:0045471 [response to ethanol]
GO:0045759 [negative regulation of action potential]
GO:0045776 [negative regulation of blood pressure]
GO:0045777 [positive regulation of blood pressure]
GO:0050796 [regulation of insulin secretion]
GO:0051001 [negative regulation of nitric-oxide synthase activity]
GO:0051966 [regulation of synaptic transmission, glutamatergic]
GO:0060135 [maternal process involved in female pregnancy]
GO:0060259 [regulation of feeding behavior]
GO:0060405 [regulation of penile erection]

439

49.1

CNR1-005

ENSP00000412192
ENST00000428600

P21554
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P21554 [Direct mapping]
Cannabinoid receptor 1
Q9BYY6 [Target identity:69%; Query identity:100%]
Cannabinoid receptor 1
F8W187 [Target identity:16%; Query identity:100%]
Cannabinoid receptor 1

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472

52.9

CNR1-006

ENSP00000358511
ENST00000369499

P21554
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P21554 [Direct mapping]
Cannabinoid receptor 1
Q9BYY6 [Target identity:69%; Query identity:100%]
Cannabinoid receptor 1
F8W187 [Target identity:16%; Query identity:100%]
Cannabinoid receptor 1

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472

52.9

CNR1-007

ENSP00000446702
ENST00000551417

F8W187
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F8W187 [Target identity:100%; Query identity:100%]
Cannabinoid receptor 1

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GO:0002866 [positive regulation of acute inflammatory response to antigenic stimulus]
GO:0004949 [cannabinoid receptor activity]
GO:0005792 [microsome]
GO:0005886 [plasma membrane]
GO:0006950 [response to stress]
GO:0007283 [spermatogenesis]
GO:0007568 [aging]
GO:0007584 [response to nutrient]
GO:0007613 [memory]
GO:0008144 [drug binding]
GO:0010976 [positive regulation of neuron projection development]
GO:0016021 [integral to membrane]
GO:0019233 [sensory perception of pain]
GO:0031622 [positive regulation of fever generation]
GO:0031999 [negative regulation of fatty acid beta-oxidation]
GO:0032228 [regulation of synaptic transmission, GABAergic]
GO:0032496 [response to lipopolysaccharide]
GO:0033004 [negative regulation of mast cell activation]
GO:0033602 [negative regulation of dopamine secretion]
GO:0035094 [response to nicotine]
GO:0042220 [response to cocaine]
GO:0043065 [positive regulation of apoptotic process]
GO:0043271 [negative regulation of ion transport]
GO:0043278 [response to morphine]
GO:0045471 [response to ethanol]
GO:0045759 [negative regulation of action potential]
GO:0045776 [negative regulation of blood pressure]
GO:0045777 [positive regulation of blood pressure]
GO:0050796 [regulation of insulin secretion]
GO:0051001 [negative regulation of nitric-oxide synthase activity]
GO:0051966 [regulation of synaptic transmission, glutamatergic]
GO:0060135 [maternal process involved in female pregnancy]
GO:0060259 [regulation of feeding behavior]
GO:0060405 [regulation of penile erection]

8.7

CNR1-201

ENSP00000442689
ENST00000535130

P21554
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P21554 [Direct mapping]
Cannabinoid receptor 1
Q9BYY6 [Target identity:69%; Query identity:100%]
Cannabinoid receptor 1
F8W187 [Target identity:16%; Query identity:100%]
Cannabinoid receptor 1

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472

52.9

CNR1-202

ENSP00000441046
ENST00000537554

P21554
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P21554 [Direct mapping]
Cannabinoid receptor 1
Q9BYY6 [Target identity:69%; Query identity:100%]
Cannabinoid receptor 1
F8W187 [Target identity:16%; Query identity:100%]
Cannabinoid receptor 1

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472

52.9

CNR1-203

ENSP00000449549
ENST00000549716

P21554
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P21554 [Direct mapping]
Cannabinoid receptor 1

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GO:0002866 [positive regulation of acute inflammatory response to antigenic stimulus]
GO:0004949 [cannabinoid receptor activity]
GO:0005792 [microsome]
GO:0005886 [plasma membrane]
GO:0005887 [integral to plasma membrane]
GO:0006950 [response to stress]
GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger]
GO:0007188 [G-protein signaling, coupled to cAMP nucleotide second messenger]
GO:0007283 [spermatogenesis]
GO:0007568 [aging]
GO:0007584 [response to nutrient]
GO:0007610 [behavior]
GO:0007613 [memory]
GO:0008144 [drug binding]
GO:0010976 [positive regulation of neuron projection development]
GO:0019233 [sensory perception of pain]
GO:0031622 [positive regulation of fever generation]
GO:0031999 [negative regulation of fatty acid beta-oxidation]
GO:0032228 [regulation of synaptic transmission, GABAergic]
GO:0032496 [response to lipopolysaccharide]
GO:0033004 [negative regulation of mast cell activation]
GO:0033602 [negative regulation of dopamine secretion]
GO:0035094 [response to nicotine]
GO:0038171 [cannabinoid signaling pathway]
GO:0042220 [response to cocaine]
GO:0043065 [positive regulation of apoptotic process]
GO:0043271 [negative regulation of ion transport]
GO:0043278 [response to morphine]
GO:0045471 [response to ethanol]
GO:0045759 [negative regulation of action potential]
GO:0045776 [negative regulation of blood pressure]
GO:0045777 [positive regulation of blood pressure]
GO:0050796 [regulation of insulin secretion]
GO:0051001 [negative regulation of nitric-oxide synthase activity]
GO:0051966 [regulation of synaptic transmission, glutamatergic]
GO:0060135 [maternal process involved in female pregnancy]
GO:0060259 [regulation of feeding behavior]
GO:0060405 [regulation of penile erection]

411

45.9

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.