PKD2

GENE INFORMATION

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Gene name

PKD2 (HGNC Symbol)

Synonyms

Pc-2, PC2, PKD4, TRPP2

Description

polycystic kidney disease 2 (autosomal dominant) (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the polycystin protein family. The encoded protein is a multi-pass membrane protein that functions as a calcium permeable cation channel, and is involved in calcium transport and calcium signaling in renal epithelial cells. This protein interacts with polycystin 1, and they may be partners in a common signaling cascade involved in tubular morphogenesis. Mutations in this gene are associated with autosomal dominant polycystic kidney disease type 2. [provided by RefSeq, Mar 2011]

Chromosome

4 (Chromosome progress)

Cytoband

q22.1

Chromosome location (bp)

88928820 - 88998929

Ensembl

ENSG00000118762 (version 73.37)

Entrez gene

5311

UniProt

Q13563 (UniProt - Evidence at protein level)

neXtProt

NX_Q13563

Antibodypedia

PKD2 antibodies
 

PROTEIN VIEW

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PKD2-001
 
PKD2-002
 
PKD2-005
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PKD2-001 ENSP00000237596
ENST00000237596
Q13563
Show all »
Show » Show » 968 109.7 No 7
PKD2-002 ENSP00000427131
ENST00000508588
B4DFN3
Show all »
Show » Show » 386 43.9 No 2
PKD2-005 ENSP00000425289
ENST00000502363
B4DFN3
Show all »
Show » Show » 386 43.9 No 2