ABCG2

GENE INFORMATION

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Gene name

ABCG2 (HGNC Symbol)

Synonyms

ABCP, BCRP, CD338, EST157481, MXR

Description

ATP-binding cassette, sub-family G (WHITE), member 2 (HGNC Symbol)

Entrez gene summary

The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

Chromosome

4 (Chromosome progress)

Cytoband

q22.1

Chromosome location (bp)

89011416 - 89152474

Ensembl

ENSG00000118777 (version 73.37)

Entrez gene

9429

UniProt

Q9UNQ0 (UniProt - Evidence at protein level)

neXtProt

NX_Q9UNQ0

Antibodypedia

ABCG2 antibodies
 

PROTEIN VIEW

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ABCG2-001
 
ABCG2-002
 
ABCG2-003
 
ABCG2-004
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ABCG2-001 ENSP00000237612
ENST00000237612
Q9UNQ0
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Show » Show » 655 72.3 No 6
ABCG2-002 ENSP00000426917
ENST00000515655
Q9UNQ0
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Show » Show » 611 67.5 No 6
ABCG2-003 ENSP00000426916
ENST00000505480
H0YAF1
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150 15.9 No 0
ABCG2-004 ENSP00000426934
ENST00000503830
H0YAF3
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130 13.6 No 0