CCND2

GENE INFORMATION

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Gene name

CCND2

Synonyms

Description

cyclin D2 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors. [provided by RefSeq, Oct 2008]

Chromosome

12 (Chromosome progress)

Cytoband

p13.32

Chromosome location (bp)

4382938 - 4414516

Ensembl

ENSG00000118971 (version 73.37)

Entrez gene

894

UniProt

P30279 (UniProt - Evidence at protein level)

neXtProt

NX_P30279

Antibodypedia

CCND2 antibodies
 

PROTEIN VIEW

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CCND2-001
 
CCND2-004
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CCND2-001 ENSP00000261254
ENST00000261254
P30279
Show all »
Show » Show » 289 33.1 No 0
CCND2-004 ENSP00000442807
ENST00000536537
Show » 170 19 No 0