TRPM6

GENE INFORMATION

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Gene name

TRPM6 (HGNC Symbol)

Synonyms

CHAK2, FLJ22628, HOMG, HSH

Description

transient receptor potential cation channel, subfamily M, member 6 (HGNC Symbol)

Entrez gene summary

This gene is predominantly expressed in the kidney and colon, and encodes a protein containing an ion channel domain and a protein kinase domain. It is crucial for magnesium homeostasis, and plays an essential role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Mutations in this gene are associated with hypomagnesemia with secondary hypocalcemia. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Apr 2010]

Chromosome

9 (Chromosome progress)

Cytoband

q21.13

Chromosome location (bp)

77337411 - 77503010

Ensembl

ENSG00000119121 (version 73.37)

Entrez gene

140803

UniProt

Q9BX84 (UniProt - Evidence at protein level)

neXtProt

NX_Q9BX84

Antibodypedia

TRPM6 antibodies
 

PROTEIN VIEW

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TRPM6-001
 
TRPM6-002
 
TRPM6-201
 
TRPM6-202
 
TRPM6-203
 
TRPM6-204
 
TRPM6-205
 
TRPM6-206
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TRPM6-001 ENSP00000354006
ENST00000360774
Q9BX84
Show all »
Show » Show » 2022 231.7 No 7
TRPM6-002 ENSP00000351942
ENST00000359047
Q96LV9
Show all »
Show » 303 34.3 No 0
TRPM6-201 ENSP00000354962
ENST00000361255
Q9BX84
Show all »
Show » Show » 2017 231 No 7
TRPM6-202 ENSP00000366060
ENST00000376864
F8W9E6
Show all »
Show » Show » 1947 223.6 No 7
TRPM6-203 ENSP00000366067
ENST00000376871
G8JLG6
Show all »
Show » Show » 859 98 No 0
TRPM6-204 ENSP00000366068
ENST00000376872
G8JLG7
Show all »
Show » Show » 977 111.8 No 0
TRPM6-205 ENSP00000396672
ENST00000449912
Q9BX84
Show all »
Show » Show » 2017 231 No 7
TRPM6-206 ENSP00000407341
ENST00000451710
F8WAD9
Show all »
Show » Show » 2026 232.2 No 7