PIGZ

GENERAL INFORMATION

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Gene name

PIGZ

Gene description

Phosphatidylinositol glycan anchor biosynthesis, class Z

Protein class

Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

Intracellular,Membrane,Secreted

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (colon, rectum)
GTEx:Expressed in all

Protein evidence

Evidence at transcript level

Protein localization

Membranous expression in a subset of tissues including the gastrointestinal tract gallbladder and kidney.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 2 antibodies.
HPA058599 , HPA059920
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Gallbladder

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (colon, rectum)

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

PIGZ (HGNC Symbol)

Synonyms

FLJ12768, MGC52163, SMP3

Description

Phosphatidylinositol glycan anchor biosynthesis, class Z (HGNC Symbol)

Entrez gene summary

The glycosylphosphatidylinositol (GPI) anchor is a glycolipid found on many blood cells that serves to anchor proteins to the cell surface. This gene encodes a protein that is localized to the endoplasmic reticulum, and is involved in GPI anchor biosynthesis. As shown for the yeast homolog, which is a member of a family of dolichol-phosphate-mannose (Dol-P-Man)-dependent mannosyltransferases, this protein can also add a side-branching fourth mannose to GPI precursors during the assembly of GPI anchors. [provided by RefSeq, Jul 2008]

Chromosome

3

Cytoband

q29

Chromosome location (bp)

196946343 - 196969060

Protein evidence

Evidence at transcript level (all genes)

Ensembl

ENSG00000119227 (version 78.38)

Entrez gene

80235

UniProt

Q86VD9 (UniProt - Evidence at transcript level)

neXtProt

NX_Q86VD9

Antibodypedia

PIGZ antibodies


PROTEIN BROWSER

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ENST00000412723
 
ENST00000413127
 
ENST00000443835
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PIGZ-001 ENSP00000413405
ENST00000412723
Q86VD9
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Show » Show » 579 63.5 No >9
PIGZ-002 ENSP00000405341
ENST00000413127
Show » Show » 49 5.4 Yes 0
PIGZ-004 ENSP00000389327
ENST00000443835
C9JQX2
Show all »
Show » Show » 92 10.1 No 0