PPP2R4

GENERAL INFORMATION

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Gene name

PPP2R4

Gene description

Protein phosphatase 2A activator, regulatory subunit 4

Protein class

Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

26
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic and nuclear expression in most cells.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 3 antibodies.
HPA005695 , CAB022068 , CAB035999
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Gallbladder

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

PPP2R4 (HGNC Symbol)

Synonyms

PR53, PTPA

Description

Protein phosphatase 2A activator, regulatory subunit 4 (HGNC Symbol)

Entrez gene summary

Protein phosphatase 2A is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2A holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B' family. This gene encodes a specific phosphotyrosyl phosphatase activator of the dimeric form of protein phosphatase 2A. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Chromosome

9

Cytoband

q34.11

Chromosome location (bp)

129110950 - 129148946

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000119383 (version 78.38)

Entrez gene

5524

UniProt

Q15257 (UniProt - Evidence at protein level)

neXtProt

NX_Q15257

Antibodypedia

PPP2R4 antibodies


PROTEIN BROWSER

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ENST00000337738
 
ENST00000347048
 
ENST00000348141
 
ENST00000355007
 
ENST00000357197
 
ENST00000358994
 
ENST00000393370
 
ENST00000411917
 
ENST00000414331
 
ENST00000414510
 
ENST00000417504
 
ENST00000417728
 
ENST00000419582
 
ENST00000423100
 
ENST00000432124
 
ENST00000432651
 
ENST00000434095
 
ENST00000435132
 
ENST00000435305
 
ENST00000436883
 
ENST00000440346
 
ENST00000445241
 
ENST00000452489
 
ENST00000453358
 
ENST00000455240
 
ENST00000455292
 
 » 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PPP2R4-001 ENSP00000405100
ENST00000411917
B4DDQ6
Show all »
Show » Show » 218 23.9 No 0
PPP2R4-002 ENSP00000408316
ENST00000423100
B7ZBQ0
Show all »
Show » Show » 61 6.9 No 0
PPP2R4-003 ENSP00000408726
ENST00000414510
B7ZBQ0
Show all »
Show » Show » 61 6.9 No 0
PPP2R4-004 ENSP00000393196
ENST00000435305
B4DDQ6
Show all »
Show » Show » 151 16.1 No 0
PPP2R4-005 ENSP00000394001
ENST00000419582
B7ZBQ0
Show all »
Show » Show » 61 6.9 No 0
PPP2R4-006 ENSP00000416661
ENST00000432651
B7ZBQ0
Show all »
Show » Show » 61 6.9 No 0
PPP2R4-007 ENSP00000411604
ENST00000434095
B7ZBQ0
Show all »
Show » Show » 61 6.9 No 0
PPP2R4-009 ENSP00000399069
ENST00000414331
C9IZ76
Show all »
Show » Show » 132 14.6 No 0
PPP2R4-010 ENSP00000351885
ENST00000358994
Q15257
Show all »
Show » Show » 323 36.8 No 0
PPP2R4-011 ENSP00000377036
ENST00000393370
Q15257
Show all »
Show » Show » 323 36.8 No 0
PPP2R4-012 ENSP00000395499
ENST00000455292
Q5T949
Show all »
Show » Show » 250 28.1 No 0
PPP2R4-013 ENSP00000406997
ENST00000445241
Q5T948
Show all »
Show » Show » 254 28.6 No 0
PPP2R4-014 ENSP00000387726
ENST00000435132
B7ZBQ0
Show all »
Show » Show » 61 6.9 No 0
PPP2R4-015 ENSP00000337412
ENST00000347048
Q68CR8
Show all »
Show » Show » 104 11.7 No 0
PPP2R4-016 ENSP00000347109
ENST00000355007
Q15257
Show all »
Show » Show » 281 31.9 No 0
PPP2R4-017 ENSP00000403542
ENST00000417728
A6PVN9
Show all »
Show » Show » 263 30.2 No 0
PPP2R4-018 ENSP00000393092
ENST00000453358
A6PVN8
Show all »
Show » Show » 129 14.4 No 0
PPP2R4-019 ENSP00000393796
ENST00000440346
A6PVN7
Show all »
Show » Show » 64 7.4 No 0
PPP2R4-020 ENSP00000335200
ENST00000348141
A6PVN5
Show all »
Show » Show » 329 37.4 No 0
PPP2R4-021 ENSP00000400314
ENST00000417504
A6PVN6
Show all »
Show » Show » 176 19.3 No 0
PPP2R4-022 ENSP00000396660
ENST00000455240
Show » Show » 120 13.9 No 0
PPP2R4-023 ENSP00000389312
ENST00000436883
B7ZBP9
Show all »
Show » Show » 41 4.6 No 0
PPP2R4-024 ENSP00000416522
ENST00000432124
B7ZBP7
Show all »
Show » Show » 77 8.4 No 0
PPP2R4-201 ENSP00000337448
ENST00000337738
Q15257
Show all »
Show » Show » 358 40.7 No 0
PPP2R4-202 ENSP00000349726
ENST00000357197
Q15257
Show all »
Show » Show » 294 33.5 No 0
PPP2R4-203 ENSP00000394338
ENST00000452489
A6PVN9
Show all »
Show » Show » 288 32.9 No 0