ABCD4

GENE INFORMATION

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Gene name

ABCD4 (HGNC Symbol)

Synonyms

EST352188, P70R, PMP69, PXMP1L

Description

ATP-binding cassette, sub-family D (ALD), member 4 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. The function of this peroxisomal membrane protein is unknown. However, it is speculated that it may function as a heterodimer for another peroxisomal ABC transporter and, therefore, may modify the adrenoleukodystrophy phenotype. It may also play a role in the process of peroxisome biogenesis. Alternative splicing results in at least two different transcript variants, one which is protein-coding and one which is probably not protein-coding. [provided by RefSeq, Jul 2008]

Chromosome

14 (Chromosome progress)

Cytoband

q24.3

Chromosome location (bp)

74752126 - 74769759

Ensembl

ENSG00000119688 (version 73.37)

Entrez gene

5826

UniProt

O14678 (UniProt - Evidence at protein level)

neXtProt

NX_O14678

Antibodypedia

ABCD4 antibodies
 

PROTEIN VIEW

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 « 
 
ABCD4-001
 
ABCD4-002
 
ABCD4-003
 
ABCD4-004
 
ABCD4-009
 
ABCD4-012
 
ABCD4-014
 
ABCD4-018
 
ABCD4-019
 
ABCD4-020
 
ABCD4-021
 
ABCD4-022
 
ABCD4-023
 
ABCD4-026
 
ABCD4-028
 
ABCD4-029
 
ABCD4-031
 
ABCD4-201
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ABCD4-001 ENSP00000349396
ENST00000356924
O14678
Show all »
Show » Show » 606 68.6 No 5
ABCD4-002 ENSP00000436782
ENST00000481935
E9PI46
Show all »
Show » Show » 56 6.2 No 1
ABCD4-003 ENSP00000434626
ENST00000469672
E9PPB6
Show all »
39 4 No 0
ABCD4-004 ENSP00000436527
ENST00000460308
E9PI46
Show all »
Show » Show » 56 6.2 No 1
ABCD4-009 ENSP00000432630
ENST00000470637
E9PI46
Show all »
Show » Show » 56 6.2 No 1
ABCD4-012 ENSP00000434792
ENST00000481348
184 19.9 No 0
ABCD4-014 ENSP00000432557
ENST00000474270
Show » 173 18.4 No 0
ABCD4-018 ENSP00000451778
ENST00000553745
E9PPB6
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39 4 No 0
ABCD4-019 ENSP00000450611
ENST00000553486
E9PI46
Show all »
Show » Show » 56 6.2 No 1
ABCD4-020 ENSP00000450491
ENST00000556119
E9PPB6
Show all »
39 4 No 0
ABCD4-021 ENSP00000451770
ENST00000556971
Show » Show » 205 23.8 No 3
ABCD4-022 ENSP00000451521
ENST00000555617
E9PPB6
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39 4 No 0
ABCD4-023 ENSP00000451993
ENST00000557588
G3V4U7
Show all »
Show » Show » 203 23.7 No 2
ABCD4-026 ENSP00000450960
ENST00000556517
184 19.9 No 0
ABCD4-028 ENSP00000450982
ENST00000555904
Show » Show » 158 17.9 No 0
ABCD4-029 ENSP00000451457
ENST00000554453
G3V3W1
Show all »
Show » Show » 98 10.1 No 0
ABCD4-031 ENSP00000452430
ENST00000553998
Show » 94 10.3 No 0
ABCD4-201 ENSP00000298816
ENST00000298816
F8W7M4
Show all »
Show » Show » 488 55.2 No 3