BCL11A

GENE INFORMATION

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Gene name

BCL11A (HGNC Symbol)

Synonyms

BCL11A-L, BCL11A-S, BCL11A-XL, CTIP1, EVI9, HBFQTL5, ZNF856

Description

B-cell CLL/lymphoma 11A (zinc finger protein) (HGNC Symbol)

Entrez gene summary

This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

2 (Chromosome progress)

Cytoband

p16.1

Chromosome location (bp)

60678302 - 60780702

Ensembl

ENSG00000119866 (version 73.37)

Entrez gene

53335

UniProt

Q9H165 (UniProt - Evidence at protein level)

neXtProt

NX_Q9H165

Antibodypedia

BCL11A antibodies
 

PROTEIN VIEW

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BCL11A-001
 
BCL11A-002
 
BCL11A-003
 
BCL11A-006
 
BCL11A-201
 
BCL11A-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

BCL11A-001 ENSP00000338774
ENST00000335712
Q9H165
Show all »
Show » Show » 835 91.2 No 0
BCL11A-002 ENSP00000349300
ENST00000356842
Q9H165
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Show » Show » 773 83.9 No 0
BCL11A-003 ENSP00000352648
ENST00000359629
Q9H165
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Show » Show » 243 26.9 No 0
BCL11A-006 ENSP00000351307
ENST00000358510
Q9H165
Show all »
Show » Show » 801 87.6 No 0
BCL11A-201 ENSP00000443712
ENST00000537768
B4DT16
Show all »
Show » Show » 442 47.9 No 0
BCL11A-202 ENSP00000438303
ENST00000538214
F5H2Y4
Show all »
Show » Show » 793 86.4 No 0