IDE

GENE INFORMATION

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Gene name

IDE

Synonyms

Description

insulin-degrading enzyme (HGNC Symbol)

Entrez gene summary

This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified.[provided by RefSeq, Sep 2009]

Chromosome

10 (Chromosome progress)

Cytoband

q23.33

Chromosome location (bp)

94211441 - 94333833

Ensembl

ENSG00000119912 (version 73.37)

Entrez gene

3416

UniProt

P14735 (UniProt - Evidence at protein level)

neXtProt

NX_P14735

Antibodypedia

IDE antibodies
 

PROTEIN VIEW

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IDE-001
 
IDE-002
 
IDE-007
 
IDE-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

IDE-001 ENSP00000265986
ENST00000265986
P14735
Show all »
Show » Show » 1019 118 Yes 0
IDE-002 ENSP00000473506
ENST00000478361
R4GN65
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61 7 Yes 0
IDE-007 ENSP00000408850
ENST00000436178
Q5T5N3
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Show » 257 29.2 No 0
IDE-201 ENSP00000360637
ENST00000371581
P14735
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Show » Show » 464 54.2 No 0