WDR11

GENERAL INFORMATION

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Gene name

WDR11

Gene description

WD repeat domain 11

Protein class

Disease related genes
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

Intracellular,Membrane

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Most of the normal tissues displayed weak to moderate cytoplasmic positivity with additional membranous staining in a few cases. Strong staining was observed in seminiferous ducts and fallopian tubes. Blood vessels were distinctly stained. Bile ducts, glial cells, bone marrow poietic cells and spleen were mainly negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA038980
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

WDR11 (HGNC Symbol)

Synonyms

BRWD2, DR11, FLJ10506, HH14, KIAA1351, WDR15

Description

WD repeat domain 11 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is located in the chromosome 10q25-26 region, which is frequently deleted in gliomas and tumors of other tissues, and is disrupted by the t(10;19) translocation rearrangement in glioblastoma cells. The gene location suggests that it is a candidate gene for the tumor suppressor locus. [provided by RefSeq, Jul 2008]

Chromosome

10

Cytoband

q26.12

Chromosome location (bp)

120851175 - 120909524

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000120008 (version 78.38)

Entrez gene

55717

UniProt

Q9BZH6 (UniProt - Evidence at protein level)

neXtProt

NX_Q9BZH6

Antibodypedia

WDR11 antibodies


PROTEIN BROWSER

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ENST00000263461
 
ENST00000604585
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

WDR11-001 ENSP00000263461
ENST00000263461
Q9BZH6
Show all »
Show » Show » 1224 136.7 No 1
WDR11-016 ENSP00000474880
ENST00000604585
S4R3Z0
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Show » Show » 312 34.3 No 0